Cholesterol oxidation products and their biological importance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F16%3A00472250" target="_blank" >RIV/61388963:_____/16:00472250 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/16:00468638

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.chemphyslip.2016.03.001" target="_blank" >http://dx.doi.org/10.1016/j.chemphyslip.2016.03.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chemphyslip.2016.03.001" target="_blank" >10.1016/j.chemphyslip.2016.03.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cholesterol oxidation products and their biological importance

Popis výsledku v původním jazyce

The main biological cause of oxysterols is the oxidation of cholesterol. They differ from cholesterol by the presence of additional polar groups that are typically hydroxyl, keto, hydroperoxy, epoxy, or carboxyl moieties. Under typical conditions, oxysterol concentration is maintained at a very low and precisely regulated level, with an excess of cholesterol. Like cholesterol, many oxysterols are hydrophobic and hence confined to cell membranes. However, small chemical differences between the sterols can significantly affect how they interact with other membrane components, and this in turn can have a substantial effect on membrane properties. In this spirit, this review describes the biological importance and the roles of oxysterols in the human body. We focus primarily on the effect of oxysterols on lipid membranes, but we also consider other issues such as enzymatic and nonenzymatic synthesis processes of oxysterols as well as pathological conditions induced by oxysterols.

Název v anglickém jazyce

Cholesterol oxidation products and their biological importance

Popis výsledku anglicky

The main biological cause of oxysterols is the oxidation of cholesterol. They differ from cholesterol by the presence of additional polar groups that are typically hydroxyl, keto, hydroperoxy, epoxy, or carboxyl moieties. Under typical conditions, oxysterol concentration is maintained at a very low and precisely regulated level, with an excess of cholesterol. Like cholesterol, many oxysterols are hydrophobic and hence confined to cell membranes. However, small chemical differences between the sterols can significantly affect how they interact with other membrane components, and this in turn can have a substantial effect on membrane properties. In this spirit, this review describes the biological importance and the roles of oxysterols in the human body. We focus primarily on the effect of oxysterols on lipid membranes, but we also consider other issues such as enzymatic and nonenzymatic synthesis processes of oxysterols as well as pathological conditions induced by oxysterols.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemistry and Physics of Lipids

ISSN

0009-3084

e-ISSN

—

Svazek periodika

199

Číslo periodika v rámci svazku

Sep

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

17

Strana od-do

144-160

Kód UT WoS článku

000381833800014

EID výsledku v databázi Scopus

2-s2.0-84959894259