Chiral analysis of alpha-diimine Ru(II) and Fe(II) complexes by capillary electrophoresis using sulfated cyclodextrins as stereoselectors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00477878" target="_blank" >RIV/61388963:_____/17:00477878 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/elps.201700077" target="_blank" >http://dx.doi.org/10.1002/elps.201700077</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201700077" target="_blank" >10.1002/elps.201700077</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chiral analysis of alpha-diimine Ru(II) and Fe(II) complexes by capillary electrophoresis using sulfated cyclodextrins as stereoselectors

Popis výsledku v původním jazyce

CE using randomly highly sulfated alpha-, beta-, and gamma-CDs (S-alpha-CD, S-beta-CD, S-gamma-CD), sulfobutylether-beta-CD (SBE-beta-CD), single isomer (6-O-sulfo) alpha-, beta-, and gamma-CDs, and their derivatives as stereoselectors was applied to chiral analysis of polypyridyl complexes of [Ru(bpy)(3)](2+), [Ru(phen)(3)](2+), and [Fe(phen)(3)](2+) (bpy = 2,2'-bipyridine, phen = 1,10 phenanthroline). The best separations of Delta- and Lambda-enantiomers of the these complexes with high resolution (up to R-1,R-2 = 7.0) and short analysis times (1020 min) were achieved in the BGE composed of 22 mM NaOH/35 mM H3PO4, pH 2.4, containing 1.56.0 mM S-alpha-CD or S-beta-CD, or SBE-beta-CD as chiral selectors. The developed method was applied to the assessment of enantiomeric purity of several samples of [Ru(bpy)(3)](2+) catalyst. CE experiments were performed in a homemade analyzer equipped with bare or hydroxypropylcellulose-coated fused-silica capillaries (total/effective length 40/29 cm, id/od 50/375 mu m) and an UV absorption detector operating at 206 nm. In addition to chiral analysis, apparent binding constants of the complexes of [Ru(bpy)(3)](2+), [Ru(phen)(3)](2+), and [Fe(phen)(3)](2+) enantiomers with five sulfated CDs (S-alpha-CD, S-beta-CD, S-gamma-CD, SBE-beta-CD, and 16Me-8S-gamma-CD) were determined from the dependence of their effective electrophoretic mobilities on the concentration of the CDs in the BGE by nonlinear regression analysis. Calculated apparent binding constants of these complexes were found to be in the (1.104.66) x 10(3) L/mol range. Moreover, it was shown that at selected concentrations of some S-CDs and suppressed or very low electroosmotic flow, the exceptional enantioseparations with infinite resolution could be achieved.

Název v anglickém jazyce

Chiral analysis of alpha-diimine Ru(II) and Fe(II) complexes by capillary electrophoresis using sulfated cyclodextrins as stereoselectors

Popis výsledku anglicky

CE using randomly highly sulfated alpha-, beta-, and gamma-CDs (S-alpha-CD, S-beta-CD, S-gamma-CD), sulfobutylether-beta-CD (SBE-beta-CD), single isomer (6-O-sulfo) alpha-, beta-, and gamma-CDs, and their derivatives as stereoselectors was applied to chiral analysis of polypyridyl complexes of [Ru(bpy)(3)](2+), [Ru(phen)(3)](2+), and [Fe(phen)(3)](2+) (bpy = 2,2'-bipyridine, phen = 1,10 phenanthroline). The best separations of Delta- and Lambda-enantiomers of the these complexes with high resolution (up to R-1,R-2 = 7.0) and short analysis times (1020 min) were achieved in the BGE composed of 22 mM NaOH/35 mM H3PO4, pH 2.4, containing 1.56.0 mM S-alpha-CD or S-beta-CD, or SBE-beta-CD as chiral selectors. The developed method was applied to the assessment of enantiomeric purity of several samples of [Ru(bpy)(3)](2+) catalyst. CE experiments were performed in a homemade analyzer equipped with bare or hydroxypropylcellulose-coated fused-silica capillaries (total/effective length 40/29 cm, id/od 50/375 mu m) and an UV absorption detector operating at 206 nm. In addition to chiral analysis, apparent binding constants of the complexes of [Ru(bpy)(3)](2+), [Ru(phen)(3)](2+), and [Fe(phen)(3)](2+) enantiomers with five sulfated CDs (S-alpha-CD, S-beta-CD, S-gamma-CD, SBE-beta-CD, and 16Me-8S-gamma-CD) were determined from the dependence of their effective electrophoretic mobilities on the concentration of the CDs in the BGE by nonlinear regression analysis. Calculated apparent binding constants of these complexes were found to be in the (1.104.66) x 10(3) L/mol range. Moreover, it was shown that at selected concentrations of some S-CDs and suppressed or very low electroosmotic flow, the exceptional enantioseparations with infinite resolution could be achieved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrophoresis

ISSN

0173-0835

e-ISSN

—

Svazek periodika

38

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

1913-1921

Kód UT WoS článku

000406724200012

EID výsledku v databázi Scopus

2-s2.0-85019105617