Paramagnetic F-19 Relaxation Enhancement in Nickel(II) Complexes of N-Trifluoroethyl Cyclam Derivatives and Cell Labeling for F-19 MRI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00482651" target="_blank" >RIV/61388963:_____/17:00482651 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/17:10365950 RIV/00216208:11320/17:10365950 RIV/00023001:_____/17:00076208

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.inorgchem.7b02119" target="_blank" >http://dx.doi.org/10.1021/acs.inorgchem.7b02119</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.inorgchem.7b02119" target="_blank" >10.1021/acs.inorgchem.7b02119</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Paramagnetic F-19 Relaxation Enhancement in Nickel(II) Complexes of N-Trifluoroethyl Cyclam Derivatives and Cell Labeling for F-19 MRI

Popis výsledku v původním jazyce

1,8-Bis(2,2,2-trifluoroethyl)cyclam (te2f) derivatives with two coordinating pendant arms involving methylenecarboxylic acid (H(2)te2f2a), methylenephosphonic acid (H(4)te2f2p), (2-pyridyl)methyl (te2f2py), and 2-aminoethyl arms (te2f2ae) in 4,11-positions were prepared, and their nickel(II) complexes were investigated as possible F-19 MR tracers. The solid-state structures of several synthetic intermediates, ligands, and all complexes were confirmed by Xray diffraction analysis. The average Ni center dot center dot center dot F distances were determined to be about 5.2 angstrom. All complexes exhibit a trans-III cyclam conformation with pendant arms bound in the apical positions. Kinetic inertness of the complexes is increased in the ligand order te2f2ae << te2f < te2f2py approximate to H(4)te2f2p << H(2)te2f2a. The [Ni(te2f2a)] complex is the most kinetically inert Ni(II) complex reported so far. Paramagnetic divalent nickel caused a shortening of F-19 NMR relaxation time down to the millisecond range. Solubility, stability, and cell toxicity were only satisfactory for the [Ni(te2f2p)](2-) complex This complex was visualized by F-19 MRI utilizing an ultrashort echo time (UTE) imaging pulse sequence, which led to an increase in sensitivity gain. Mesenchymal stem cells were successfully loaded with the complex (up to 0.925/5.55 pg Ni/F per cell). F-19 MRI using a UTE pulse sequence provided images with a good signal-to-noise ratio within the measurement time, as short as tens of minutes. The data thus proved a major sensitivity gain in F-19 MRI achieved by utilization of the paramagnetic (transition) metal complex as F-19 MR tracers coupled with the optimal fast imaging protocol.

Název v anglickém jazyce

Paramagnetic F-19 Relaxation Enhancement in Nickel(II) Complexes of N-Trifluoroethyl Cyclam Derivatives and Cell Labeling for F-19 MRI

Popis výsledku anglicky

1,8-Bis(2,2,2-trifluoroethyl)cyclam (te2f) derivatives with two coordinating pendant arms involving methylenecarboxylic acid (H(2)te2f2a), methylenephosphonic acid (H(4)te2f2p), (2-pyridyl)methyl (te2f2py), and 2-aminoethyl arms (te2f2ae) in 4,11-positions were prepared, and their nickel(II) complexes were investigated as possible F-19 MR tracers. The solid-state structures of several synthetic intermediates, ligands, and all complexes were confirmed by Xray diffraction analysis. The average Ni center dot center dot center dot F distances were determined to be about 5.2 angstrom. All complexes exhibit a trans-III cyclam conformation with pendant arms bound in the apical positions. Kinetic inertness of the complexes is increased in the ligand order te2f2ae << te2f < te2f2py approximate to H(4)te2f2p << H(2)te2f2a. The [Ni(te2f2a)] complex is the most kinetically inert Ni(II) complex reported so far. Paramagnetic divalent nickel caused a shortening of F-19 NMR relaxation time down to the millisecond range. Solubility, stability, and cell toxicity were only satisfactory for the [Ni(te2f2p)](2-) complex This complex was visualized by F-19 MRI utilizing an ultrashort echo time (UTE) imaging pulse sequence, which led to an increase in sensitivity gain. Mesenchymal stem cells were successfully loaded with the complex (up to 0.925/5.55 pg Ni/F per cell). F-19 MRI using a UTE pulse sequence provided images with a good signal-to-noise ratio within the measurement time, as short as tens of minutes. The data thus proved a major sensitivity gain in F-19 MRI achieved by utilization of the paramagnetic (transition) metal complex as F-19 MR tracers coupled with the optimal fast imaging protocol.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

13337-13348

Kód UT WoS článku

000414820100073

EID výsledku v databázi Scopus

2-s2.0-85033384263