Evaluation of an ion source with a tubular nebulizer for microflow atmospheric pressure chemical ionization

Kód výsledku v IS VaVaI

RIV/61388963:_____/18:00490859 - isvavai.cz

Nalezeny alternativní kódy

RIV/00216208:11310/18:10391624

Výsledek na webu

http://dx.doi.org/10.1007/s00706-018-2172-4

DOI - Digital Object Identifier

10.1007/s00706-018-2172-4

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of an ion source with a tubular nebulizer for microflow atmospheric pressure chemical ionization

Popis výsledku v původním jazyce

An atmospheric pressure chemical ionization (APCI) source designed for microliter-per-minute flow rates (0.5-10.0 mm(3)/min) was constructed. A simple resistively heated 1/8 in. OD tube-based nebulizer, together with a corona-discharge electrode was positioned in front of the entrance capillary of a mass spectrometer. Working parameters of the ion source were optimized, and its performance was evaluated. The limit of detection for directly infused acridine was found to be lower for micro-APCI (10 fmol/s) than for conventional APCI (170 fmol/s), and the linear dynamic range was significantly wider for the micro-APCI source. The micro-APCI and conventional APCI sources provided similar, but not identical mass spectra. The micro-APCI source was used as a detector for high-performance liquid chromatography at 10 mm(3)/min, the limit of detection for acridine was 690 fmol, which was about ten times lower value than in conventional HPLC.

Název v anglickém jazyce

Evaluation of an ion source with a tubular nebulizer for microflow atmospheric pressure chemical ionization

Popis výsledku anglicky

An atmospheric pressure chemical ionization (APCI) source designed for microliter-per-minute flow rates (0.5-10.0 mm(3)/min) was constructed. A simple resistively heated 1/8 in. OD tube-based nebulizer, together with a corona-discharge electrode was positioned in front of the entrance capillary of a mass spectrometer. Working parameters of the ion source were optimized, and its performance was evaluated. The limit of detection for directly infused acridine was found to be lower for micro-APCI (10 fmol/s) than for conventional APCI (170 fmol/s), and the linear dynamic range was significantly wider for the micro-APCI source. The micro-APCI and conventional APCI sources provided similar, but not identical mass spectra. The micro-APCI source was used as a detector for high-performance liquid chromatography at 10 mm(3)/min, the limit of detection for acridine was 690 fmol, which was about ten times lower value than in conventional HPLC.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

GA16-01639S: Mikro- a nanoprůtokové ionizace za atmosferického tlaku pro bioanalytickou hmotnostní spektrometrii

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte fur Chemie

ISSN

0026-9247

e-ISSN

—

Svazek periodika

149

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

8

Strana od-do

987-994

Kód UT WoS článku

000433333300001

EID výsledku v databázi Scopus

2-s2.0-85042070102