A Comparison of Protein and mRNA Expression during Development of the Soil Dwelling Prokaryote (S. coelicolor)
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00531246" target="_blank" >RIV/61388963:_____/20:00531246 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61388971:_____/20:00531246
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/pmic.202000032" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/pmic.202000032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pmic.202000032" target="_blank" >10.1002/pmic.202000032</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A Comparison of Protein and mRNA Expression during Development of the Soil Dwelling Prokaryote (S. coelicolor)
Popis výsledku v původním jazyce
In this paper, correlation analysis of protein and mRNA levels in the soil dwelling bacteriaStreptomyces coelicolor(S. coelicolorM145) is presented during development of the population as it grew in liquid medium using three biological and two technical replicates, measured during exponential growth, and its entry into the stationary phase. The proteome synthesis time series are compared with the gene expression time series measured previously under identical experimental conditions. Results reveal that about one third of protein/mRNA synthesis profiles are well correlated while another third are correlated negatively. Functional analysis of the highly correlated groups is presented. Based on numerical simulation, the negative correlation between protein and mRNA is shown to be caused by the difference between the rate of translation and protein degradation.
Název v anglickém jazyce
A Comparison of Protein and mRNA Expression during Development of the Soil Dwelling Prokaryote (S. coelicolor)
Popis výsledku anglicky
In this paper, correlation analysis of protein and mRNA levels in the soil dwelling bacteriaStreptomyces coelicolor(S. coelicolorM145) is presented during development of the population as it grew in liquid medium using three biological and two technical replicates, measured during exponential growth, and its entry into the stationary phase. The proteome synthesis time series are compared with the gene expression time series measured previously under identical experimental conditions. Results reveal that about one third of protein/mRNA synthesis profiles are well correlated while another third are correlated negatively. Functional analysis of the highly correlated groups is presented. Based on numerical simulation, the negative correlation between protein and mRNA is shown to be caused by the difference between the rate of translation and protein degradation.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Proteomics
ISSN
1615-9853
e-ISSN
—
Svazek periodika
20
Číslo periodika v rámci svazku
14
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
5
Strana od-do
2000032
Kód UT WoS článku
000543743200001
EID výsledku v databázi Scopus
2-s2.0-85087156886