Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00578949" target="_blank" >RIV/61388963:_____/23:00578949 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61388971:_____/23:00578949
Výsledek na webu
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/41/75" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/41/75</a>
DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics
Popis výsledku v původním jazyce
Rifamycin-derived antibiotics are highly efficient inhibitors of prokaryotic DNA-dependent RNA polymerase (RNAP) used in treatment of many bacterial infections, including tuberculosis. During exposure, however, bacteria develop resistance to antibiotics, and several modifications of rifamycin skeleton that inhibit RNAP binding have already been discovered. A photo-crosslinking probe 1(Fig. 1) with biotin handle based on rifamycin B was recently used for identifying specific protein that displaces antibiotic from RNAP in Streptomyces venezulae.
Název v anglickém jazyce
Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics
Popis výsledku anglicky
Rifamycin-derived antibiotics are highly efficient inhibitors of prokaryotic DNA-dependent RNA polymerase (RNAP) used in treatment of many bacterial infections, including tuberculosis. During exposure, however, bacteria develop resistance to antibiotics, and several modifications of rifamycin skeleton that inhibit RNAP binding have already been discovered. A photo-crosslinking probe 1(Fig. 1) with biotin handle based on rifamycin B was recently used for identifying specific protein that displaces antibiotic from RNAP in Streptomyces venezulae.

Projekt
<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Podobné výsledky(10)