Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00582665" target="_blank" >RIV/61388963:_____/24:00582665 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/tcr.202300282" target="_blank" >https://doi.org/10.1002/tcr.202300282</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/tcr.202300282" target="_blank" >10.1002/tcr.202300282</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets

Popis výsledku v původním jazyce

Parkinson's disease is a yet incurable, age-related neurodegenerative disorder characterized by the aggregation of small neuronal protein alpha-synuclein into amyloid fibrils. Inhibition of this process is a prospective strategy for developing a disease-modifying treatment. We overview here small molecule, peptide, and protein inhibitors of alpha-synuclein fibrillization reported to date. Special attention was paid to the specificity of inhibitors and critical analysis of their action mechanisms. Namely, the importance of oxidation of polyphenols and cross-linking of alpha-synuclein into inhibitory dimers was highlighted. We also compared strategies of targeting monomeric, oligomeric, and fibrillar alpha-synuclein species, thoroughly discussed the strong and weak sides of different approaches to testing the inhibitors.

Název v anglickém jazyce

Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets

Popis výsledku anglicky

Parkinson's disease is a yet incurable, age-related neurodegenerative disorder characterized by the aggregation of small neuronal protein alpha-synuclein into amyloid fibrils. Inhibition of this process is a prospective strategy for developing a disease-modifying treatment. We overview here small molecule, peptide, and protein inhibitors of alpha-synuclein fibrillization reported to date. Special attention was paid to the specificity of inhibitors and critical analysis of their action mechanisms. Namely, the importance of oxidation of polyphenols and cross-linking of alpha-synuclein into inhibitory dimers was highlighted. We also compared strategies of targeting monomeric, oligomeric, and fibrillar alpha-synuclein species, thoroughly discussed the strong and weak sides of different approaches to testing the inhibitors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Record

ISSN

1527-8999

e-ISSN

1528-0691

Svazek periodika

24

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

23

Strana od-do

e202300282

Kód UT WoS článku

001095814700001

EID výsledku v databázi Scopus

2-s2.0-85175372523