Analogues of Insulin, IGF1, and IGF2 for Studying the Biological Functions of Hormones and Their Receptors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00639671" target="_blank" >RIV/61388963:_____/25:00639671 - isvavai.cz</a>

Výsledek na webu

<a href="https://hdl.handle.net/11104/0370137" target="_blank" >https://hdl.handle.net/11104/0370137</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Analogues of Insulin, IGF1, and IGF2 for Studying the Biological Functions of Hormones and Their Receptors

Popis výsledku v původním jazyce

Our research group at the Institute of Organic Chemistry and Biochemistry in Prague is focused on all aspects of insulin and insulin-like growth factors 1 and 2 (IGF1/2) physiology. Our general goal is to understand the structural basis for the different cellular responses triggered by insulin and IGFs. We synthesize analogs and mimetics of insulin and IGFs to study their interactions with cognate receptors and to develop new candidate drugs for the treatment of hormone-related disorders. In this lecture, I will summarize our results with insulin, IGF-1, and IGF-2 analogs that have modified binding affinities toward their cognate receptors, and I will demonstrate that these intriguing compounds can be highly useful for studying interactions and functional relationships within the insulin–IGF system, as well as for potential therapeutic applications.nThis publication was supported by the National Institute for Research on Metabolic and Cardiovascular Diseases (EXCELES Program, ID LX22NPO5104) – Funded by the European Union – Next Generation

Název v anglickém jazyce

Analogues of Insulin, IGF1, and IGF2 for Studying the Biological Functions of Hormones and Their Receptors

Popis výsledku anglicky

Our research group at the Institute of Organic Chemistry and Biochemistry in Prague is focused on all aspects of insulin and insulin-like growth factors 1 and 2 (IGF1/2) physiology. Our general goal is to understand the structural basis for the different cellular responses triggered by insulin and IGFs. We synthesize analogs and mimetics of insulin and IGFs to study their interactions with cognate receptors and to develop new candidate drugs for the treatment of hormone-related disorders. In this lecture, I will summarize our results with insulin, IGF-1, and IGF-2 analogs that have modified binding affinities toward their cognate receptors, and I will demonstrate that these intriguing compounds can be highly useful for studying interactions and functional relationships within the insulin–IGF system, as well as for potential therapeutic applications.nThis publication was supported by the National Institute for Research on Metabolic and Cardiovascular Diseases (EXCELES Program, ID LX22NPO5104) – Funded by the European Union – Next Generation

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů