Interaction of late apoptotic and necrotic cells with vitronectin
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F11%3A00365171" target="_blank" >RIV/61388971:_____/11:00365171 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378050:_____/11:00365171 RIV/00023736:_____/11:00009193
Výsledek na webu
<a href="http://dx.doi.org/10.1371/journal.pone.0019243" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0019243</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0019243" target="_blank" >10.1371/journal.pone.0019243</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Interaction of late apoptotic and necrotic cells with vitronectin
Popis výsledku v původním jazyce
Vitronectin (Vn) is an abundant plasma glycoprotein identified also as a part of extracellular matrix. Vn is substantially enriched at sites of injured, fibrosing, inflamed, and tumor tissues where it is believed to be involved in wound healing and tissue remodeling. Little is known about the mechanism of Vn localization into the damaged tissues. 2E12 antibody has been described to bind a subset of late apoptotic cells. The antigen recognized by 2E12 antibody was identified as Vn. Vn binds to the late apoptotic and necrotic cells in cell cultures in vitro as well as in murine thymus and spleen in vivo. Confocal microscopy revealed that Vn binds to an intracellular cytoplasmic structure after the membrane rupture. Vitronectin could serve as a marker ofmembrane disruption in necrosis and apoptosis for flow cytometry analysis. Vn binding to dead cells may represent one of the mechanisms of Vn incorporation into the injured tissues.
Název v anglickém jazyce
Interaction of late apoptotic and necrotic cells with vitronectin
Popis výsledku anglicky
Vitronectin (Vn) is an abundant plasma glycoprotein identified also as a part of extracellular matrix. Vn is substantially enriched at sites of injured, fibrosing, inflamed, and tumor tissues where it is believed to be involved in wound healing and tissue remodeling. Little is known about the mechanism of Vn localization into the damaged tissues. 2E12 antibody has been described to bind a subset of late apoptotic cells. The antigen recognized by 2E12 antibody was identified as Vn. Vn binds to the late apoptotic and necrotic cells in cell cultures in vitro as well as in murine thymus and spleen in vivo. Confocal microscopy revealed that Vn binds to an intracellular cytoplasmic structure after the membrane rupture. Vitronectin could serve as a marker ofmembrane disruption in necrosis and apoptosis for flow cytometry analysis. Vn binding to dead cells may represent one of the mechanisms of Vn incorporation into the injured tissues.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/1M0506" target="_blank" >1M0506: Centrum molekulární a buněčné imunologie</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
PLoS ONE
ISSN
1932-6203
e-ISSN
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Svazek periodika
6
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
"e19243"
Kód UT WoS článku
000290224800019
EID výsledku v databázi Scopus
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