Hormonal activities of new brominated flame retardants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00390233" target="_blank" >RIV/61388971:_____/12:00390233 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.chemosphere.2011.12.049" target="_blank" >http://dx.doi.org/10.1016/j.chemosphere.2011.12.049</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chemosphere.2011.12.049" target="_blank" >10.1016/j.chemosphere.2011.12.049</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hormonal activities of new brominated flame retardants

Popis výsledku v původním jazyce

After the phase-out of two commercial mixtures of brominated flame retardants, an increasing number of alternative flame retardants have been introduced in commercial applications. None of them, however, has been thoroughly tested for its hormonal activity. We used two yeast reporter-gene assays to determine the potential of eleven compounds to interfere with estrogenic and androgenic pathways. Our data demonstrate the ability of 2,4,6-tribromophenol to lower the transcriptional activity of human estrogen and androgen receptors. A nominal IC50 value of 14.1 mu M for anti-estrogenic and 3.9 mu M for anti-androgenic activity was obtained using the luciferase reporter. An IC50 value of 9.2 mu M was calculated for the anti-estrogenic activity measured by the beta-galactosidase assay. Of the tested chemicals, this study highlights the endocrine disrupting effects of 2,4,6-tribromophenol whose occurrence in the environment should be monitored

Název v anglickém jazyce

Hormonal activities of new brominated flame retardants

Popis výsledku anglicky

After the phase-out of two commercial mixtures of brominated flame retardants, an increasing number of alternative flame retardants have been introduced in commercial applications. None of them, however, has been thoroughly tested for its hormonal activity. We used two yeast reporter-gene assays to determine the potential of eleven compounds to interfere with estrogenic and androgenic pathways. Our data demonstrate the ability of 2,4,6-tribromophenol to lower the transcriptional activity of human estrogen and androgen receptors. A nominal IC50 value of 14.1 mu M for anti-estrogenic and 3.9 mu M for anti-androgenic activity was obtained using the luciferase reporter. An IC50 value of 9.2 mu M was calculated for the anti-estrogenic activity measured by the beta-galactosidase assay. Of the tested chemicals, this study highlights the endocrine disrupting effects of 2,4,6-tribromophenol whose occurrence in the environment should be monitored

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA104%2F09%2F0694" target="_blank" >GA104/09/0694: Komplexní fotokatalytické procesy - Nanotechnologie pro životní prostředí</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemosphere

ISSN

0045-6535

e-ISSN

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Svazek periodika

87

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

820-824

Kód UT WoS článku

000303787300021

EID výsledku v databázi Scopus

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