Beta-N-Acetylhexosaminidases: group-specific inhibitors wanted

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00395482" target="_blank" >RIV/61388971:_____/13:00395482 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1039/9781849737173-00102" target="_blank" >http://dx.doi.org/10.1039/9781849737173-00102</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/9781849737173-00102" target="_blank" >10.1039/9781849737173-00102</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Beta-N-Acetylhexosaminidases: group-specific inhibitors wanted

Popis výsledku v původním jazyce

Beta-N-Acetylhexosaminidases (GH20) and ?-N-acetylglucosaminidases (GH84) are two genetically and functionally unrelated classes of glycosidases sharing the substrate-assisted catalytic mechanism and architecture of their active sites. In humans, the deficiency of these enzymes causes severe neurodegenerative disorders (GH20) and Alzheimer?s disease (GH84). For the research of the physiological functions of these enzymes, inhibitors selective for just one of the enzyme families must be employed in orderto avoid the generation of complex phenotypes. The search for highly potent and selective inhibitor sis based on the known common and distinct features of these enzyme groups, profiting from the crystal structures of the enzyme-inhibitor complexes. In this chapter, the most studied inhibitor scaffolds such as NAG-thiazoline, PUGNAc and GlcNAcstatins and their rationally designed analogues are described and discussed, providing an actual survey of the most efficient and selective compoun

Název v anglickém jazyce

Beta-N-Acetylhexosaminidases: group-specific inhibitors wanted

Popis výsledku anglicky

Beta-N-Acetylhexosaminidases (GH20) and ?-N-acetylglucosaminidases (GH84) are two genetically and functionally unrelated classes of glycosidases sharing the substrate-assisted catalytic mechanism and architecture of their active sites. In humans, the deficiency of these enzymes causes severe neurodegenerative disorders (GH20) and Alzheimer?s disease (GH84). For the research of the physiological functions of these enzymes, inhibitors selective for just one of the enzyme families must be employed in orderto avoid the generation of complex phenotypes. The search for highly potent and selective inhibitor sis based on the known common and distinct features of these enzyme groups, profiting from the crystal structures of the enzyme-inhibitor complexes. In this chapter, the most studied inhibitor scaffolds such as NAG-thiazoline, PUGNAc and GlcNAcstatins and their rationally designed analogues are described and discussed, providing an actual survey of the most efficient and selective compoun

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP13-06818P" target="_blank" >GP13-06818P: Nové syntetické přístupy s využitím mutantní a přirozené beta-N-acetylhexosaminidasy z Talaromyces flavus</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Carbohydrate Chemistry

ISBN

978-1-84973-587-2

Počet stran výsledku

18

Strana od-do

102-119

Počet stran knihy

246

Název nakladatele

The Royal Society of Chemistry

Místo vydání

Cambridge

Kód UT WoS kapitoly

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