The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00425609" target="_blank" >RIV/61388971:_____/13:00425609 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1042/BJ20120312" target="_blank" >http://dx.doi.org/10.1042/BJ20120312</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/BJ20120312" target="_blank" >10.1042/BJ20120312</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

Popis výsledku v původním jazyce

On solid substrates, yeast colonies pass through distinct developmental phases characterized by the changes in pH of their surroundings from acidic to nearly alkaline and vice versa. At the beginning of the alkali phase colonies start to produce ammonia,which functions as a quorum-sensing molecule inducing the reprogramming of cell metabolism. Such reprogramming includes, among others, the activation of several plasma membrane transporters and is connected with colony differentiation. In the present study, we show that colony cells can use two transport mechanisms to import lactic acid: a 'saturable' component of the transport, which requires the presence of a functional Jen1p transporter, and a 'non-saturable' component (diffusion) that is independent of Jen1p. During colony development, the efficiency of both transport components changes similarly in central and outer colonial cells. Although the lactate uptake capacity of central cells gradually decreases during colony development,

Název v anglickém jazyce

The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

Popis výsledku anglicky

On solid substrates, yeast colonies pass through distinct developmental phases characterized by the changes in pH of their surroundings from acidic to nearly alkaline and vice versa. At the beginning of the alkali phase colonies start to produce ammonia,which functions as a quorum-sensing molecule inducing the reprogramming of cell metabolism. Such reprogramming includes, among others, the activation of several plasma membrane transporters and is connected with colony differentiation. In the present study, we show that colony cells can use two transport mechanisms to import lactic acid: a 'saturable' component of the transport, which requires the presence of a functional Jen1p transporter, and a 'non-saturable' component (diffusion) that is independent of Jen1p. During colony development, the efficiency of both transport components changes similarly in central and outer colonial cells. Although the lactate uptake capacity of central cells gradually decreases during colony development,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA204%2F08%2F0718" target="_blank" >GA204/08/0718: Role amoniakové signalizace při diferenciaci kvasinkových kolonií, jejich vývoji, stárnutí a přežívání: Molekulární mechanismy a funkce.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochemical Journal

ISSN

0264-6021

e-ISSN

—

Svazek periodika

454

Číslo periodika v rámci svazku

SEP 2013

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

551-558

Kód UT WoS článku

000329975400019

EID výsledku v databázi Scopus

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