Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00433022" target="_blank" >RIV/61388971:_____/14:00433022 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jbm.a.34873" target="_blank" >http://dx.doi.org/10.1002/jbm.a.34873</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.a.34873" target="_blank" >10.1002/jbm.a.34873</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine

Popis výsledku v původním jazyce

Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The resultsindicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels

Název v anglickém jazyce

Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine

Popis výsledku anglicky

Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The resultsindicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP301%2F12%2F1254" target="_blank" >GAP301/12/1254: Překonání přirozené a mnohočetné lékové rezistence nádor-selektivní akumulací inhibitorů ABC transportérů/Bcl-2 či léčebného genu pod PEG-3 promotorem</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biomedical Materials Research. Part A

ISSN

1549-3296

e-ISSN

—

Svazek periodika

102

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1982-1990

Kód UT WoS článku

000334488800036

EID výsledku v databázi Scopus

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