Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00433507" target="_blank" >RIV/61388971:_____/14:00433507 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s12026-014-8549-5" target="_blank" >http://dx.doi.org/10.1007/s12026-014-8549-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12026-014-8549-5" target="_blank" >10.1007/s12026-014-8549-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

Popis výsledku v původním jazyce

Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that especially affects neonates within the "critical window" of immunological development. PRRS was recognized in 1987 and within a few years became pandemic causing an estimated yearly $600,000 economic loss in the USA with comparative losses in most other countries. The causative agent is a single-stranded, positive-sense enveloped arterivirus (PRRSV) that infects macrophages and plasmacytoid dendritic cells. Despite thediscovery of PRRSV in 1991 and the publication of > 2,000 articles, the control of PRRS is problematic. Despite the large volume of literature on this disease, the cellular and molecular mechanisms describing how PRRSV dysregulates the host immune system are poorly understood. We know that PRRSV suppresses innate immunity and causes abnormal B cell proliferation and repertoire development, often lymphopenia and thymic atrophy. The PRRSV genome is highly diverse, rapidly evolving but ame

Název v anglickém jazyce

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

Popis výsledku anglicky

Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that especially affects neonates within the "critical window" of immunological development. PRRS was recognized in 1987 and within a few years became pandemic causing an estimated yearly $600,000 economic loss in the USA with comparative losses in most other countries. The causative agent is a single-stranded, positive-sense enveloped arterivirus (PRRSV) that infects macrophages and plasmacytoid dendritic cells. Despite thediscovery of PRRSV in 1991 and the publication of > 2,000 articles, the control of PRRS is problematic. Despite the large volume of literature on this disease, the cellular and molecular mechanisms describing how PRRSV dysregulates the host immune system are poorly understood. We know that PRRSV suppresses innate immunity and causes abnormal B cell proliferation and repertoire development, often lymphopenia and thymic atrophy. The PRRSV genome is highly diverse, rapidly evolving but ame

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunologic Research

ISSN

0257-277X

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

1-3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

28

Strana od-do

81-108

Kód UT WoS článku

000340369900010

EID výsledku v databázi Scopus

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