Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00435341" target="_blank" >RIV/61388971:_____/14:00435341 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389005:_____/14:00435341 RIV/61388963:_____/14:00435341 RIV/68407700:21460/14:00227809

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c4nr02570a" target="_blank" >http://dx.doi.org/10.1039/c4nr02570a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c4nr02570a" target="_blank" >10.1039/c4nr02570a</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds

Popis výsledku v původním jazyce

Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and nanoscale sensing. Although initial studies indicate that these small gems are biocompatible, there is a great deal of variability in synthesis methods and surface functionalization that has yet to be evaluated. Here we present a comprehensive analysis of the cellular compatibility of an array of nanodiamond subtypes and surface functionalization strategies. These results demonstrate that NDs are well tolerated by multiple cell types at both functional and gene expression levels. In addition, ND-mediated delivery of daunorubicin is less toxic to multiple cell types than treatment with daunorubicin alone, thus demonstrating the ability of the ND agent to improve drug tolerance and decrease therapeutic toxicity. Overall, the results here indicate that ND biocompatibility serves as a promising foundation for continued preclinical inves

Název v anglickém jazyce

Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds

Popis výsledku anglicky

Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and nanoscale sensing. Although initial studies indicate that these small gems are biocompatible, there is a great deal of variability in synthesis methods and surface functionalization that has yet to be evaluated. Here we present a comprehensive analysis of the cellular compatibility of an array of nanodiamond subtypes and surface functionalization strategies. These results demonstrate that NDs are well tolerated by multiple cell types at both functional and gene expression levels. In addition, ND-mediated delivery of daunorubicin is less toxic to multiple cell types than treatment with daunorubicin alone, thus demonstrating the ability of the ND agent to improve drug tolerance and decrease therapeutic toxicity. Overall, the results here indicate that ND biocompatibility serves as a promising foundation for continued preclinical inves

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/LM2011019" target="_blank" >LM2011019: CANAM ? příspěvek k provozu a k reinvesticím Centra urychlovačů a jaderných analytických metod</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanoscale

ISSN

2040-3364

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

20

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

11712-11721

Kód UT WoS článku

000343000800018

EID výsledku v databázi Scopus

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