The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00456148" target="_blank" >RIV/61388971:_____/15:00456148 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.dci.2015.02.014" target="_blank" >http://dx.doi.org/10.1016/j.dci.2015.02.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dci.2015.02.014" target="_blank" >10.1016/j.dci.2015.02.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets

Popis výsledku v původním jazyce

Porcine ileum is populated with a high proportion of B cells but previous studies have shown that they are not developed there. While B cells prevail in the ileum even in germ-free animals, microbial colonization is a major factor that causes even a greater prevalence of B cells in the ileum and further differential representation of lymphoid cells throughout small intestine. Analysis of lymphoid subpopulations showed that the effector cells appear only after colonization. These include class-switched IgM(+)IgA(+) B cells, primed CD2(-)CD21(+) B cells, antibody-producing/memory CD2(+)CD21(-) B cells, and effector/memory CD4(+)CD8(+) alpha beta Th cells. While colonization resulted in a uniform distribution of effector cells throughout the gut, it caused a decrease in the frequency of cytotoxic alpha beta and CD2(+)CD8(+) gamma delta T cells. These results suggest that the ileum is a site where naive B cells expand presumably to increase antibody repertoire but the entire small intestin

Název v anglickém jazyce

The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets

Popis výsledku anglicky

Porcine ileum is populated with a high proportion of B cells but previous studies have shown that they are not developed there. While B cells prevail in the ileum even in germ-free animals, microbial colonization is a major factor that causes even a greater prevalence of B cells in the ileum and further differential representation of lymphoid cells throughout small intestine. Analysis of lymphoid subpopulations showed that the effector cells appear only after colonization. These include class-switched IgM(+)IgA(+) B cells, primed CD2(-)CD21(+) B cells, antibody-producing/memory CD2(+)CD21(-) B cells, and effector/memory CD4(+)CD8(+) alpha beta Th cells. While colonization resulted in a uniform distribution of effector cells throughout the gut, it caused a decrease in the frequency of cytotoxic alpha beta and CD2(+)CD8(+) gamma delta T cells. These results suggest that the ileum is a site where naive B cells expand presumably to increase antibody repertoire but the entire small intestin

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP502%2F12%2F0110" target="_blank" >GAP502/12/0110: Úloha gamadelta T buněk při imunizaci naivního imunitního systému prasat</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Developmental and Comparative Immunology

ISSN

0145-305X

e-ISSN

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Svazek periodika

51

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

99-107

Kód UT WoS článku

000357906800012

EID výsledku v databázi Scopus

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