Aspergillus infection monitored by multimodal imaging in a rat model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00462011" target="_blank" >RIV/61388971:_____/16:00462011 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/16:33161330 RIV/61989592:15110/16:33161330

Výsledek na webu

<a href="http://dx.doi.org/10.1002/pmic.201500487" target="_blank" >http://dx.doi.org/10.1002/pmic.201500487</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/pmic.201500487" target="_blank" >10.1002/pmic.201500487</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Aspergillus infection monitored by multimodal imaging in a rat model

Popis výsledku v původním jazyce

Although myriads of experimental approaches have been published in the field of fungal infection diagnostics, interestingly, in 21st century there is no satisfactory early noninvasive tool for Aspergillus diagnostics with good sensitivity and specificity. In this work, we for the first time described the fungal burden in rat lungs by multimodal imaging approach. The Aspergillus infection was monitored by positron emission tomography and light microscopy employing modified Grocott's methenamine silver staining and eosin counterstaining. Laser ablation inductively coupled plasma mass spectrometry imaging has revealed a dramatic iron increase in fungi-affected areas, which can be presumably attributed to microbial siderophores. Quantitative elemental data were inferred from matrix-matched standards prepared from rat lungs.

Název v anglickém jazyce

Aspergillus infection monitored by multimodal imaging in a rat model

Popis výsledku anglicky

Although myriads of experimental approaches have been published in the field of fungal infection diagnostics, interestingly, in 21st century there is no satisfactory early noninvasive tool for Aspergillus diagnostics with good sensitivity and specificity. In this work, we for the first time described the fungal burden in rat lungs by multimodal imaging approach. The Aspergillus infection was monitored by positron emission tomography and light microscopy employing modified Grocott's methenamine silver staining and eosin counterstaining. Laser ablation inductively coupled plasma mass spectrometry imaging has revealed a dramatic iron increase in fungi-affected areas, which can be presumably attributed to microbial siderophores. Quantitative elemental data were inferred from matrix-matched standards prepared from rat lungs.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Proteomics

ISSN

1615-9853

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

11-12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1785-1792

Kód UT WoS článku

000379049100023

EID výsledku v databázi Scopus

2-s2.0-84974856023