Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00464251" target="_blank" >RIV/61388971:_____/16:00464251 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/16:10326040 RIV/00669806:_____/16:10326040

Výsledek na webu

<a href="http://dx.doi.org/10.21873/anticanres.11037" target="_blank" >http://dx.doi.org/10.21873/anticanres.11037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.11037" target="_blank" >10.21873/anticanres.11037</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer

Popis výsledku v původním jazyce

Background/Aim: Current research of prostate cancer (PCa) offers a promising way of identifying patients with adverse prognosis who do benefit from radical treatment that can affect quality of life as resections are associated with numerous side-effects. The aim of our study was to evaluate the relationship of TMPRSS2-ERG fusion gene status, tumor tissue prostate-specific antigen (PSA), prostate cancer antigen 3 (PCA3), miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy. Patients and Methods: The study group consisted of 108 patients who underwent radical prostatectomy. PSA was measured in peripheral blood collected preoperativelly. The expression of TMPRSS2-ERG transcript and the expression of miR-23b, miR-26a and miR-221 in formalin-fixed, paraffin-embedded (FFPE) tumor tissues was analyzed by reverse transcription (RT) real-time polymerase chain reaction (PCR).

Název v anglickém jazyce

Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer

Popis výsledku anglicky

Background/Aim: Current research of prostate cancer (PCa) offers a promising way of identifying patients with adverse prognosis who do benefit from radical treatment that can affect quality of life as resections are associated with numerous side-effects. The aim of our study was to evaluate the relationship of TMPRSS2-ERG fusion gene status, tumor tissue prostate-specific antigen (PSA), prostate cancer antigen 3 (PCA3), miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy. Patients and Methods: The study group consisted of 108 patients who underwent radical prostatectomy. PSA was measured in peripheral blood collected preoperativelly. The expression of TMPRSS2-ERG transcript and the expression of miR-23b, miR-26a and miR-221 in formalin-fixed, paraffin-embedded (FFPE) tumor tissues was analyzed by reverse transcription (RT) real-time polymerase chain reaction (PCR).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

7

Strana od-do

4787-4793

Kód UT WoS článku

000384001800057

EID výsledku v databázi Scopus

2-s2.0-84991728589