Nitrile-Converting Enzymes and their Synthetic Applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00465386" target="_blank" >RIV/61388971:_____/16:00465386 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/9781118828083.ch12" target="_blank" >http://dx.doi.org/10.1002/9781118828083.ch12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9781118828083.ch12" target="_blank" >10.1002/9781118828083.ch12</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nitrile-Converting Enzymes and their Synthetic Applications

Popis výsledku v původním jazyce

The enzymatic hydrolysis of nitriles proceeds via two different pathways: a two step pathway catalyzed by nitrile hydratase and amidase, and a single‐step pathway catalyzed by nitrilase. Nitrile hydratase and nitrilase belong to different protein superfamilies, and their phylogenetic distribution is also different (nitrilases in plants, fungi, and bacteria but nitrile hydratases almost exclusively in bacteria). Nitrilases (EC 3.5.5.‐.) belong to the nitrilase superfamily, that is, nonpeptide C-N hydrolases with a Glu‐Lys‐Cys catalytic triad, and nitrile hydratasesn(4.2.1.84) are metalloenzymes containing a ferric or a cobalt (III) ion in their catalytic site. Due to their ability to transform an immense number of man‐made nitriles, the nitrile‐converting enzymes have found widespread use in synthetic organic chemistry. The advantages of enzymatic processes reside in their mild conditions, high yields, and high purities of the products and in their regio‐ or enantioselectivities.n

Název v anglickém jazyce

Nitrile-Converting Enzymes and their Synthetic Applications

Popis výsledku anglicky

The enzymatic hydrolysis of nitriles proceeds via two different pathways: a two step pathway catalyzed by nitrile hydratase and amidase, and a single‐step pathway catalyzed by nitrilase. Nitrile hydratase and nitrilase belong to different protein superfamilies, and their phylogenetic distribution is also different (nitrilases in plants, fungi, and bacteria but nitrile hydratases almost exclusively in bacteria). Nitrilases (EC 3.5.5.‐.) belong to the nitrilase superfamily, that is, nonpeptide C-N hydrolases with a Glu‐Lys‐Cys catalytic triad, and nitrile hydratasesn(4.2.1.84) are metalloenzymes containing a ferric or a cobalt (III) ion in their catalytic site. Due to their ability to transform an immense number of man‐made nitriles, the nitrile‐converting enzymes have found widespread use in synthetic organic chemistry. The advantages of enzymatic processes reside in their mild conditions, high yields, and high purities of the products and in their regio‐ or enantioselectivities.n

Druh

C - Kapitola v odborné knize

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP504%2F11%2F0394" target="_blank" >GAP504/11/0394: Mezidruhová analýza rekombinantních nitrilas exprimovaných z hypotetických sekvencí, jejich význam a potenciální aplikace v životním prostředí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Green Biocatalysis

ISBN

9781118822296

Počet stran výsledku

19

Strana od-do

331-350

Počet stran knihy

762

Název nakladatele

John Wiley & Sons

Místo vydání

Hoboken, New Jersey

Kód UT WoS kapitoly

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