Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00465577" target="_blank" >RIV/61388971:_____/16:00465577 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/16:00059991

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2016/7320275" target="_blank" >http://dx.doi.org/10.1155/2016/7320275</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2016/7320275" target="_blank" >10.1155/2016/7320275</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES

Popis výsledku v původním jazyce

Aims. The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches. Methods. Thirty pigs were randomized to transgastric, transcolonic, or laparoscopic peritoneoscopy. Blood was drawn and analyzed for C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-(IL-) 1 beta, IL-6, WBCs, and platelets. Results. Endoscopic closure with an OTSC was successful in all 20 animals. The postoperative course was uneventful in all animals. CRP values rose on day 1 in all animals and slowly declined to baseline levels on day 14 with no differences between the groups(p > 0.05, NS). The levels of TNF-alpha. were significantly increased in the transcolonic group (p < 0.01); however this difference was already present prior to the procedure and remained unchanged. No differences were observed in IL1-beta. and IL-6 values. There was a temporary rise of WBC on day 1 and of platelets on day 7 in all groups (p > 0.05, NS). Conclusions. Transgastric, transcolonic, and laparoscopic peritoneoscopy resulted in similar changes in systemic inflammatory markers. Our findings do not support the assumption that NOTES is less invasive than laparoscopy.

Název v anglickém jazyce

Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES

Popis výsledku anglicky

Aims. The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches. Methods. Thirty pigs were randomized to transgastric, transcolonic, or laparoscopic peritoneoscopy. Blood was drawn and analyzed for C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-(IL-) 1 beta, IL-6, WBCs, and platelets. Results. Endoscopic closure with an OTSC was successful in all 20 animals. The postoperative course was uneventful in all animals. CRP values rose on day 1 in all animals and slowly declined to baseline levels on day 14 with no differences between the groups(p > 0.05, NS). The levels of TNF-alpha. were significantly increased in the transcolonic group (p < 0.01); however this difference was already present prior to the procedure and remained unchanged. No differences were observed in IL1-beta. and IL-6 values. There was a temporary rise of WBC on day 1 and of platelets on day 7 in all groups (p > 0.05, NS). Conclusions. Transgastric, transcolonic, and laparoscopic peritoneoscopy resulted in similar changes in systemic inflammatory markers. Our findings do not support the assumption that NOTES is less invasive than laparoscopy.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NS10525" target="_blank" >NS10525: Transluminální chirurgická endoskopie ? systémová odpověď a bakteriální translokace v závislosti na místě vstupu do dutiny břišní</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gastroenterology Research and Practice

ISSN

1687-6121

e-ISSN

—

Svazek periodika

2016

Číslo periodika v rámci svazku

MAY

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000378709800001

EID výsledku v databázi Scopus

2-s2.0-84976593472