Gut microbiota: puppeteer of the host juvenile growth

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00489196" target="_blank" >RIV/61388971:_____/18:00489196 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1097/MCO.0000000000000463" target="_blank" >http://dx.doi.org/10.1097/MCO.0000000000000463</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MCO.0000000000000463" target="_blank" >10.1097/MCO.0000000000000463</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gut microbiota: puppeteer of the host juvenile growth

Popis výsledku v původním jazyce

Purpose of reviewThis review focuses on the recent discoveries about the impact of intestinal microbiota on mammalian host juvenile growth.Recent findingsIntestinal microbiota is a powerful modulator of many facets of multicellular host's physiology. Recent results from human field studies and animal research have clearly shown that not only the nutrition, but also the intestinal microbiota impacts host postnatal growth kinetics. Absence of microbiome leads to stunted growth in mammalian gnotobiotic models and changes in the composition of the intestinal microbiota can impact the postnatal growth kinetics both positively and negatively under normal nutritional conditions as well as in undernutrition. Strikingly, specific bacterial strains are able to interact with GH/IGF-1 somatotropic axis activity, thus directly impacting host juvenile development.SummaryIntestinal microbiota dictates the pace of host postnatal growth. This newly described role envisages that therapy with specific bacterial strains, together with re-nutritional strategies, might successfully alleviate the long-term sequelae of undernutrition during childhood in humans.

Název v anglickém jazyce

Gut microbiota: puppeteer of the host juvenile growth

Popis výsledku anglicky

Purpose of reviewThis review focuses on the recent discoveries about the impact of intestinal microbiota on mammalian host juvenile growth.Recent findingsIntestinal microbiota is a powerful modulator of many facets of multicellular host's physiology. Recent results from human field studies and animal research have clearly shown that not only the nutrition, but also the intestinal microbiota impacts host postnatal growth kinetics. Absence of microbiome leads to stunted growth in mammalian gnotobiotic models and changes in the composition of the intestinal microbiota can impact the postnatal growth kinetics both positively and negatively under normal nutritional conditions as well as in undernutrition. Strikingly, specific bacterial strains are able to interact with GH/IGF-1 somatotropic axis activity, thus directly impacting host juvenile development.SummaryIntestinal microbiota dictates the pace of host postnatal growth. This newly described role envisages that therapy with specific bacterial strains, together with re-nutritional strategies, might successfully alleviate the long-term sequelae of undernutrition during childhood in humans.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/GJ18-07015Y" target="_blank" >GJ18-07015Y: Objasnění významu střevních bakterií a specifických bakteriálních kmenů pro postnatální růst myši za normálních nutričních podmínek a při podvýživě</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Clinical Nutrition and Metabolic Care

ISSN

1363-1950

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

179-183

Kód UT WoS článku

000429435500007

EID výsledku v databázi Scopus

2-s2.0-85045183836