Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00573086" target="_blank" >RIV/68378050:_____/23:00573086 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/23:00573086

Výsledek na webu

<a href="https://www.science.org/doi/10.1126/science.ade9767" target="_blank" >https://www.science.org/doi/10.1126/science.ade9767</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/science.ade9767" target="_blank" >10.1126/science.ade9767</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

Popis výsledku v původním jazyce

The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJLsustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.

Název v anglickém jazyce

Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

Popis výsledku anglicky

The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJLsustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science

ISSN

0036-8075

e-ISSN

1095-9203

Svazek periodika

379

Číslo periodika v rámci svazku

6634 SI

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

826-833

Kód UT WoS článku

000981616600014

EID výsledku v databázi Scopus

2-s2.0-85148680225