The role of the gut microbiota and Lactiplantibacillus plantarum wjl strain in Juvenile growth during chronic undernutritionn

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00580480" target="_blank" >RIV/61388971:_____/23:00580480 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.old-herborn-university.de/wp-content/uploads/publications/books/OHUni_book_35_article_2.pdf" target="_blank" >https://www.old-herborn-university.de/wp-content/uploads/publications/books/OHUni_book_35_article_2.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The role of the gut microbiota and Lactiplantibacillus plantarum wjl strain in Juvenile growth during chronic undernutritionn

Popis výsledku v původním jazyce

The World Health Organization defines malnutrition as a deficiency, excess, or imbalance in a person's energy and/or nutrient intake. However, it is becoming increasingly clear that not only diet per se, but also the intestinal microbiota plays a fundamental role in the development of diseases associated with malnutrition. Next-generation sequencing, the renewed interest in bac- terial culturing techniques, and the use of gnotobiotic models have enabled major advances in causally linking the role of the microbiota and specificnbacterial strains in the aetiology/prevention of diseases associated with undernutrition, including wasting, stunting, and underweight. We have shown that the Lactiplantibacillus plantarum strain, selected in the gnotobiotic invertebrate Drosophila model for its growth-promoting properties, is able to increase the growth of juvenile undernourished mice in both gnotobiotic and specific pathogen-free animals, and that this effect is dependent on the expression of the NOD2 receptor by intestinal epithelial cells. These results suggest that administration of selected bacterial strains may represent a novel strategy for alleviating the persistent stunting that is one of the long-term consequences of undernutrition, which still affects millions of children under five years of age in low- and middle-income countries.

Název v anglickém jazyce

The role of the gut microbiota and Lactiplantibacillus plantarum wjl strain in Juvenile growth during chronic undernutritionn

Popis výsledku anglicky

The World Health Organization defines malnutrition as a deficiency, excess, or imbalance in a person's energy and/or nutrient intake. However, it is becoming increasingly clear that not only diet per se, but also the intestinal microbiota plays a fundamental role in the development of diseases associated with malnutrition. Next-generation sequencing, the renewed interest in bac- terial culturing techniques, and the use of gnotobiotic models have enabled major advances in causally linking the role of the microbiota and specificnbacterial strains in the aetiology/prevention of diseases associated with undernutrition, including wasting, stunting, and underweight. We have shown that the Lactiplantibacillus plantarum strain, selected in the gnotobiotic invertebrate Drosophila model for its growth-promoting properties, is able to increase the growth of juvenile undernourished mice in both gnotobiotic and specific pathogen-free animals, and that this effect is dependent on the expression of the NOD2 receptor by intestinal epithelial cells. These results suggest that administration of selected bacterial strains may represent a novel strategy for alleviating the persistent stunting that is one of the long-term consequences of undernutrition, which still affects millions of children under five years of age in low- and middle-income countries.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/GM21-19640M" target="_blank" >GM21-19640M: Specifické bakteriální kmeny a definovaná postbiotika odvozená z bakterií pro zlepšení dlouhodobých následků podvýživy</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů