Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00504644" target="_blank" >RIV/61388971:_____/19:00504644 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/19:00504644 RIV/67985823:_____/19:00504644 RIV/68407700:21460/19:00339420

Výsledek na webu

<a href="https://doi.org/10.1002/pssb.201800424" target="_blank" >https://doi.org/10.1002/pssb.201800424</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/pssb.201800424" target="_blank" >10.1002/pssb.201800424</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons

Popis výsledku v původním jazyce

This article examines the ability of newly developed nanostructured porous boron-doped diamond (BDD) to form an interface with neural cells and the role of molecular functionalization by a polymer on this interface. Due to its high stability, biocompatibility, and electrical properties, BDD is a promising material for construction of neuroelectrodes. Nanostructuring and an increase in the surface specific area can further improve the sensitivity and performance of such electrodes. Here, porous BDD prepared in a multistep diamond deposition on a porous template consisting of a polymer and electrospun SiO2 fibers is examined. This work shows that this new material is biocompatible and does not exhibit any cytotoxicity on fibroblast cell lines. Further, this work shows that porous BDD supports regeneration of newborn and adult neurons when functionalized with poly-L-lysine.

Název v anglickém jazyce

Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons

Popis výsledku anglicky

This article examines the ability of newly developed nanostructured porous boron-doped diamond (BDD) to form an interface with neural cells and the role of molecular functionalization by a polymer on this interface. Due to its high stability, biocompatibility, and electrical properties, BDD is a promising material for construction of neuroelectrodes. Nanostructuring and an increase in the surface specific area can further improve the sensitivity and performance of such electrodes. Here, porous BDD prepared in a multistep diamond deposition on a porous template consisting of a polymer and electrospun SiO2 fibers is examined. This work shows that this new material is biocompatible and does not exhibit any cytotoxicity on fibroblast cell lines. Further, this work shows that porous BDD supports regeneration of newborn and adult neurons when functionalized with poly-L-lysine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

—

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physica Status Solidi B-Basic Solid State Physics

ISSN

0370-1972

e-ISSN

—

Svazek periodika

256

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

1800424

Kód UT WoS článku

000461236600009

EID výsledku v databázi Scopus

2-s2.0-85059164245