The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00531162" target="_blank" >RIV/61388971:_____/20:00531162 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.plos.org/plosgenetics/article?rev=1&id=10.1371/journal.pgen.1008275" target="_blank" >https://journals.plos.org/plosgenetics/article?rev=1&id=10.1371/journal.pgen.1008275</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pgen.1008275" target="_blank" >10.1371/journal.pgen.1008275</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

Popis výsledku v původním jazyce

We observed that the second messenger (p)ppGpp, known to be synthesized by the ribosome-associated Rel synthetase upon nutrient starvation during the stringent response, is also intricately involved in the stress response of B. subtilis cells and can act as a pleiotropic regulator during the adaptation to heat stress. (p)ppGpp can slow down and modulate translation and is, together with the transcriptional stress regulator Spx, partially involved in the transcriptional down-regulation of the translation machinery. The stress-induced elevation of cellular (p)ppGpp levels confers increased stress tolerance and facilitates an improved protein homeostasis by modulating translation and reducing the load on the protein quality control system.

Název v anglickém jazyce

The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

Popis výsledku anglicky

We observed that the second messenger (p)ppGpp, known to be synthesized by the ribosome-associated Rel synthetase upon nutrient starvation during the stringent response, is also intricately involved in the stress response of B. subtilis cells and can act as a pleiotropic regulator during the adaptation to heat stress. (p)ppGpp can slow down and modulate translation and is, together with the transcriptional stress regulator Spx, partially involved in the transcriptional down-regulation of the translation machinery. The stress-induced elevation of cellular (p)ppGpp levels confers increased stress tolerance and facilitates an improved protein homeostasis by modulating translation and reducing the load on the protein quality control system.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS Genetics

ISSN

1553-7404

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

34

Strana od-do

e1008275

Kód UT WoS článku

000524758200046

EID výsledku v databázi Scopus

2-s2.0-85082542735