Protective Activities of Mucosal Antibodies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00535967" target="_blank" >RIV/61388971:_____/20:00535967 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-811924-2.00004-3" target="_blank" >10.1016/B978-0-12-811924-2.00004-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Protective Activities of Mucosal Antibodies

Popis výsledku v původním jazyce

Extensive studies of mucosal antibodies actively induced by immunization and infection or passively administered to nonimmunized subjects have convincingly demonstrated the essential role of antibodies in the prevention of mucosally acquired infections. Mucosal antibodies display their protective functions by several mechanisms, depending on their levels and antigen specificity in various external secretions, Ig isotype association, which differs in the intestinal versus genitourinary tract, molecular form, such as monomeric and polymeric Ig, and highly variable glycosylation patterns. The inhibition of antigen uptake, antibody and glycan-mediated interference with microbial attachment to epithelial cell receptors, intraluminal aggregation of bacteria, and the ability to neutralize biologically active antigens such as viruses and bacterial products represent the major protective mechanism of mucosal antibodies. The ability to induce antibodies of desired specificity and relevant effector functions in diverse external secretions, with a focus on the dominant secretory IgA isotype with its advantageous protective potential, is the most important goal in the generation of mucosal vaccines.

Název v anglickém jazyce

Protective Activities of Mucosal Antibodies

Popis výsledku anglicky

Extensive studies of mucosal antibodies actively induced by immunization and infection or passively administered to nonimmunized subjects have convincingly demonstrated the essential role of antibodies in the prevention of mucosally acquired infections. Mucosal antibodies display their protective functions by several mechanisms, depending on their levels and antigen specificity in various external secretions, Ig isotype association, which differs in the intestinal versus genitourinary tract, molecular form, such as monomeric and polymeric Ig, and highly variable glycosylation patterns. The inhibition of antigen uptake, antibody and glycan-mediated interference with microbial attachment to epithelial cell receptors, intraluminal aggregation of bacteria, and the ability to neutralize biologically active antigens such as viruses and bacterial products represent the major protective mechanism of mucosal antibodies. The ability to induce antibodies of desired specificity and relevant effector functions in diverse external secretions, with a focus on the dominant secretory IgA isotype with its advantageous protective potential, is the most important goal in the generation of mucosal vaccines.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Mucosal Vaccines

ISBN

978-0-12-811924-2

Počet stran výsledku

14

Strana od-do

71-84

Počet stran knihy

881

Název nakladatele

Academic Press Ltd- Elsevier Science Ltd

Místo vydání

Londýn

Kód UT WoS kapitoly

000538933600005