Cytoprotective Activity of Natural and Synthetic Antioxidants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00537777" target="_blank" >RIV/61388971:_____/20:00537777 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2076-3921/9/8/713/htm" target="_blank" >https://www.mdpi.com/2076-3921/9/8/713/htm</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cytoprotective Activity of Natural and Synthetic Antioxidants

Popis výsledku v původním jazyce

Numerous chronic diseases including cancer, cardiovascular, chronic respiratory or neurodegenerative diseases, diabetes mellitus, retinal damage, and others are associated with oxidative stress. Therefore, various natural and synthetic antioxidants are proposed for the prevention and treatment of such diseases . Cellular protection against oxidative and electrophile toxicitiesn(chemoprevention) can be provided either by redox-active, short-living direct antioxidants or indirect antioxidants having both anti- and prooxidant activity, activating the Keap1/Nrf2/ARE pathway, which results in the transcriptional induction of cytoprotective proteins . Individual antioxidant protective systems in humans cooperate in a complex functional interplay, cytoprotective proteins are involved in the synthesis and/or regeneration of direct antioxidants, which in turn are often required for the catalytic functions of cytoprotective proteins, which are the real ´antioxidant´ effectors . Direct antioxidant therapy often failed in clinical trials and recent studies mostly confirm the involvement of several cell signaling pathways in cytoprotection from oxidative stress.

Název v anglickém jazyce

Cytoprotective Activity of Natural and Synthetic Antioxidants

Popis výsledku anglicky

Numerous chronic diseases including cancer, cardiovascular, chronic respiratory or neurodegenerative diseases, diabetes mellitus, retinal damage, and others are associated with oxidative stress. Therefore, various natural and synthetic antioxidants are proposed for the prevention and treatment of such diseases . Cellular protection against oxidative and electrophile toxicitiesn(chemoprevention) can be provided either by redox-active, short-living direct antioxidants or indirect antioxidants having both anti- and prooxidant activity, activating the Keap1/Nrf2/ARE pathway, which results in the transcriptional induction of cytoprotective proteins . Individual antioxidant protective systems in humans cooperate in a complex functional interplay, cytoprotective proteins are involved in the synthesis and/or regeneration of direct antioxidants, which in turn are often required for the catalytic functions of cytoprotective proteins, which are the real ´antioxidant´ effectors . Direct antioxidant therapy often failed in clinical trials and recent studies mostly confirm the involvement of several cell signaling pathways in cytoprotection from oxidative stress.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LTC18003" target="_blank" >LTC18003: Metabolisums flavonolignanů silymarinu u stárnoucí populace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů