Central Modulators of Appetite in Eating Disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00574041" target="_blank" >RIV/61388971:_____/23:00574041 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/referenceworkentry/10.1007/978-3-030-97416-9_112-1" target="_blank" >https://link.springer.com/referenceworkentry/10.1007/978-3-030-97416-9_112-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-030-97416-9" target="_blank" >10.1007/978-3-030-97416-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Central Modulators of Appetite in Eating Disorders

Popis výsledku v původním jazyce

Energy balance is controlled by various long- and short-term regulatory mechanisms that influence food intake and energy expenditure. The central nervous system carries out this regulation in cooperation with many peripheral regulatory elements (hormones, neuropeptides of the gastrointestinal tract, adipose tissue, and microbiome) that interact. Generally, feeding and appetite are regulated by the dynamic interplay of homeostatic, hedonic, and cognitive (learning, inhibitory, top-down self-control) neurocircuits. Homeostatic regulation of the appetite is located mainly in the hypothalamus. Central and peripheral factors affecting food intake contribute to a complex network of hypothalamic signaling with the appetite-inhibitory and appetite-stimulatory circuits, which oppose each other. Disruption of hypothalamic homeostatic balance and a disbalance in hedonic (reward system) and cognitive (inhibitory) neurocircuits contribute to a variety of extremes in eating behavior and eating disorders. However, imbalances in any single factor involved in feeding regulation cannot explain the complexity of regulatory pathways or the multiple individual developmental factors that are thought to be associated with eating disorders. The importance of the interplay between diets, brain neurocircuits, and hypothalamus energy homeostasis must be clarified under normal and pathological conditions. Some alterations in the abundance of neuropeptides normalize after recovery in patients with anorexia nervosa (AN) or bulimia nervosa (BN), suggesting that malnutrition can cause transitional disturbances. However, imbalances do not normalize in others, and, for example, those with AN or BN often fail to reverse imbalances linked to their illness, and disease symptoms can persist long after weight recovery.

Název v anglickém jazyce

Central Modulators of Appetite in Eating Disorders

Popis výsledku anglicky

Energy balance is controlled by various long- and short-term regulatory mechanisms that influence food intake and energy expenditure. The central nervous system carries out this regulation in cooperation with many peripheral regulatory elements (hormones, neuropeptides of the gastrointestinal tract, adipose tissue, and microbiome) that interact. Generally, feeding and appetite are regulated by the dynamic interplay of homeostatic, hedonic, and cognitive (learning, inhibitory, top-down self-control) neurocircuits. Homeostatic regulation of the appetite is located mainly in the hypothalamus. Central and peripheral factors affecting food intake contribute to a complex network of hypothalamic signaling with the appetite-inhibitory and appetite-stimulatory circuits, which oppose each other. Disruption of hypothalamic homeostatic balance and a disbalance in hedonic (reward system) and cognitive (inhibitory) neurocircuits contribute to a variety of extremes in eating behavior and eating disorders. However, imbalances in any single factor involved in feeding regulation cannot explain the complexity of regulatory pathways or the multiple individual developmental factors that are thought to be associated with eating disorders. The importance of the interplay between diets, brain neurocircuits, and hypothalamus energy homeostasis must be clarified under normal and pathological conditions. Some alterations in the abundance of neuropeptides normalize after recovery in patients with anorexia nervosa (AN) or bulimia nervosa (BN), suggesting that malnutrition can cause transitional disturbances. However, imbalances do not normalize in others, and, for example, those with AN or BN often fail to reverse imbalances linked to their illness, and disease symptoms can persist long after weight recovery.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Eating Disorders

ISBN

978-3-030-97416-9

Počet stran výsledku

22

Strana od-do

—

Počet stran knihy

1161

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

—