Microbiota as the unifying factor behind the hallmarks of cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00578527" target="_blank" >RIV/61388971:_____/23:00578527 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10466860 RIV/00064165:_____/23:10466860

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00432-023-05244-6" target="_blank" >https://link.springer.com/article/10.1007/s00432-023-05244-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00432-023-05244-6" target="_blank" >10.1007/s00432-023-05244-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microbiota as the unifying factor behind the hallmarks of cancer

Popis výsledku v původním jazyce

The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management.

Název v anglickém jazyce

Microbiota as the unifying factor behind the hallmarks of cancer

Popis výsledku anglicky

The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NV19-03-00179" target="_blank" >NV19-03-00179: Potenciální využití fekální bakterioterapie u pacientů s generalizovaným nádorovým onemocněním léčeným anti-PD-1 protilátkami.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cancer Research and Clinical Oncology

ISSN

0171-5216

e-ISSN

1432-1335

Svazek periodika

149

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

22

Strana od-do

14429-14450

Kód UT WoS článku

001044879000002

EID výsledku v databázi Scopus

2-s2.0-85167368641