Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00618471" target="_blank" >RIV/61388971:_____/25:00618471 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/25:00618471 RIV/00216208:11110/25:10496389 RIV/00064203:_____/25:10496389

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0168365925002652" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0168365925002652</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jconrel.2025.113645" target="_blank" >10.1016/j.jconrel.2025.113645</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery

Popis výsledku v původním jazyce

Multidrug resistance (MDR) represents one of the major concerns in cancer therapy as it may cause reduced efficacy of chemotherapeutic drugs. The study explores the potential of novel amphiphilic diblock (DB) micelle forming copolymers composed of poly[N-(2-hydroxypropyl)methacrylamide]-based copolymers and poly(propylene oxide) to overcome MDR mechanisms. The DB copolymers and their doxorubicin (Dox) conjugates significantly inhibited drug efflux in chemoresistant cancer cells by depletion of intracellular ATP, resulting in increased Dox accumulation. Mechanisms involved in MDR inhibition are shown. Copolymers with additionally loaded PPO in the micelle core demonstrated superior efficacy in vitro and in vivo in treatment of experimental murine tumor CT26. The ATP depletion capacity was also demonstrátor in patient-derived xenograft (PDX) model.

Název v anglickém jazyce

Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery

Popis výsledku anglicky

Multidrug resistance (MDR) represents one of the major concerns in cancer therapy as it may cause reduced efficacy of chemotherapeutic drugs. The study explores the potential of novel amphiphilic diblock (DB) micelle forming copolymers composed of poly[N-(2-hydroxypropyl)methacrylamide]-based copolymers and poly(propylene oxide) to overcome MDR mechanisms. The DB copolymers and their doxorubicin (Dox) conjugates significantly inhibited drug efflux in chemoresistant cancer cells by depletion of intracellular ATP, resulting in increased Dox accumulation. Mechanisms involved in MDR inhibition are shown. Copolymers with additionally loaded PPO in the micelle core demonstrated superior efficacy in vitro and in vivo in treatment of experimental murine tumor CT26. The ATP depletion capacity was also demonstrátor in patient-derived xenograft (PDX) model.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Controlled Release

ISSN

0168-3659

e-ISSN

1873-4995

Svazek periodika

381

Číslo periodika v rámci svazku

May 10

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

17

Strana od-do

113645

Kód UT WoS článku

001457041100001

EID výsledku v databázi Scopus

2-s2.0-105000612958