Strategies for Actinobacteria Isolation, Cultivation, and Metabolite Production that Are Biologically Important

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00619380" target="_blank" >RIV/61388971:_____/25:00619380 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/25:43931738

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsomega.5c01344" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.5c01344</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsomega.5c01344" target="_blank" >10.1021/acsomega.5c01344</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Strategies for Actinobacteria Isolation, Cultivation, and Metabolite Production that Are Biologically Important

Popis výsledku v původním jazyce

Novel antimicrobial agents are urgently needed to combat antimicrobial resistance from multidrug-resistant organisms. Actinobacteria are key sources of bioactive metabolites with diverse biological activities. Despite their contributions to drug discovery, the process from strain identification to drug manufacturing faces many challenges, especially the rediscovery of known compounds. Recent technological and scientific advancements have accelerated drug development. Efforts to isolate and screen rare actinobacterial species could yield novel bioactive compounds. This review summarizes techniques for selectively isolating rare actinobacteria, improving bioactive metabolite production, and discovering potential strains. Notably, new genomic strategies and new discoveries regarding spectroscopic signature-based bioactive natural products containing specific structural motifs are also discussed. Furthermore, this review updates the compounds derived from rare actinobacteria and their biological applications.

Název v anglickém jazyce

Strategies for Actinobacteria Isolation, Cultivation, and Metabolite Production that Are Biologically Important

Popis výsledku anglicky

Novel antimicrobial agents are urgently needed to combat antimicrobial resistance from multidrug-resistant organisms. Actinobacteria are key sources of bioactive metabolites with diverse biological activities. Despite their contributions to drug discovery, the process from strain identification to drug manufacturing faces many challenges, especially the rediscovery of known compounds. Recent technological and scientific advancements have accelerated drug development. Efforts to isolate and screen rare actinobacterial species could yield novel bioactive compounds. This review summarizes techniques for selectively isolating rare actinobacteria, improving bioactive metabolite production, and discovering potential strains. Notably, new genomic strategies and new discoveries regarding spectroscopic signature-based bioactive natural products containing specific structural motifs are also discussed. Furthermore, this review updates the compounds derived from rare actinobacteria and their biological applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Omega

ISSN

2470-1343

e-ISSN

2470-1343

Svazek periodika

10

Číslo periodika v rámci svazku

16

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

15923-15934

Kód UT WoS článku

001470668300001

EID výsledku v databázi Scopus

2-s2.0-105002771367