Design of porphyrin-based conjugated microporous polymers with enhanced singlet oxygen productivity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F16%3A00460327" target="_blank" >RIV/61388980:_____/16:00460327 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/16:00460327 RIV/00216208:11310/16:10324372

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c6ra04066g" target="_blank" >http://dx.doi.org/10.1039/c6ra04066g</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6ra04066g" target="_blank" >10.1039/c6ra04066g</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Design of porphyrin-based conjugated microporous polymers with enhanced singlet oxygen productivity

Popis výsledku v původním jazyce

Novel non-toxic materials with antimicrobial surfaces are needed for medicinal applications. Potential alternatives for bacterial inactivation include materials that produce singlet oxygen, O-2((1)Delta(g)), a short-lived, highly oxidative, and cytotoxic species. We synthesized a promising group of materials, porphyrin-based conjugated microporous polymers (CMPs), which effectively generate O-2((1)Delta(g)) under visible light irradiation. CMPs were rationally designed and synthesized to maximize O-2((1)Delta(g)) production. A strategy based on three-dimensional frameworks allowed the immediate environment of the porphyrin units to be tuned and their structure-property relationships to be elucidated. We investigated the photophysical and photochemical properties of the frameworks and compared them with the properties of porphyrin-based CMPs and metal-organic frameworks. In general, the O-2((1)Delta(g)) production activity of the CMPs correlated with neither the surface area nor with the pore volume. The novel CMPs displayed high O-2((1)Delta(g)) production, were stable in organic solvents, and did not undergo measurable photobleaching.

Název v anglickém jazyce

Design of porphyrin-based conjugated microporous polymers with enhanced singlet oxygen productivity

Popis výsledku anglicky

Novel non-toxic materials with antimicrobial surfaces are needed for medicinal applications. Potential alternatives for bacterial inactivation include materials that produce singlet oxygen, O-2((1)Delta(g)), a short-lived, highly oxidative, and cytotoxic species. We synthesized a promising group of materials, porphyrin-based conjugated microporous polymers (CMPs), which effectively generate O-2((1)Delta(g)) under visible light irradiation. CMPs were rationally designed and synthesized to maximize O-2((1)Delta(g)) production. A strategy based on three-dimensional frameworks allowed the immediate environment of the porphyrin units to be tuned and their structure-property relationships to be elucidated. We investigated the photophysical and photochemical properties of the frameworks and compared them with the properties of porphyrin-based CMPs and metal-organic frameworks. In general, the O-2((1)Delta(g)) production activity of the CMPs correlated with neither the surface area nor with the pore volume. The novel CMPs displayed high O-2((1)Delta(g)) production, were stable in organic solvents, and did not undergo measurable photobleaching.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA16-15020S" target="_blank" >GA16-15020S: Fotoaktivní polymerní materiály s nanostrukturovanými povrchy pro biomedicínské aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

50

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

44279-44287

Kód UT WoS článku

000376119000052

EID výsledku v databázi Scopus

2-s2.0-84971350926