Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F18%3A00488571" target="_blank" >RIV/61388980:_____/18:00488571 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/18:00488571 RIV/00216208:11310/18:10374429 RIV/60461373:22330/18:43917384

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acsami.7b19835" target="_blank" >http://dx.doi.org/10.1021/acsami.7b19835</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsami.7b19835" target="_blank" >10.1021/acsami.7b19835</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria

Popis výsledku v původním jazyce

Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O 2 ( 1 Δ g ), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O 2 ( 1 Δ g ) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.

Název v anglickém jazyce

Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria

Popis výsledku anglicky

Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O 2 ( 1 Δ g ), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O 2 ( 1 Δ g ) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Materials and Interfaces

ISSN

1944-8244

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

8527-8535

Kód UT WoS článku

000427910800016

EID výsledku v databázi Scopus

2-s2.0-85043779819