Komplexační a biodistribuční studie komplexů 111In a 90Y s bifunkčními H4dota analogy kyseliny fosforné

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F09%3A00319937" target="_blank" >RIV/61389005:_____/09:00319937 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Complexation and biodistribution study of 111In and 90Y complexes of bifunctional phosphinic acid analogs of H4dota

Popis výsledku v původním jazyce

In this study, the complexation rates of two new phosphinate H4dota analogs, H5do3apPrA and H4do3apABn, and H4dota itself were compared under identical conditions. The biodistribution of their 111In and 90Y complexes in healthy rats was also studied. Unlike the observation obtained under ?chemical? conditions where differences between the ligands were observed no such differences in complexation rates were found under radiochemical conditions. The ligands bind the radiometals similarly to H4dota. So, ?chemical? formation kinetic data should be transferred in to radiochemical conditions only with high care and ?radiochemical? complexation experiments should be run as part of standard in vitro studies with new ligands considered as potential radiopharmaceuticals. Pharmacokinetic studies in rats showed similar distribution characteristics for both phosphinate H4dota analogs radiolabelled with 111In and 90Y when compared with that of the 111In?H4dota complex.

Název v anglickém jazyce

Complexation and biodistribution study of 111In and 90Y complexes of bifunctional phosphinic acid analogs of H4dota

Popis výsledku anglicky

In this study, the complexation rates of two new phosphinate H4dota analogs, H5do3apPrA and H4do3apABn, and H4dota itself were compared under identical conditions. The biodistribution of their 111In and 90Y complexes in healthy rats was also studied. Unlike the observation obtained under ?chemical? conditions where differences between the ligands were observed no such differences in complexation rates were found under radiochemical conditions. The ligands bind the radiometals similarly to H4dota. So, ?chemical? formation kinetic data should be transferred in to radiochemical conditions only with high care and ?radiochemical? complexation experiments should be run as part of standard in vitro studies with new ligands considered as potential radiopharmaceuticals. Pharmacokinetic studies in rats showed similar distribution characteristics for both phosphinate H4dota analogs radiolabelled with 111In and 90Y when compared with that of the 111In?H4dota complex.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/1QS100480501" target="_blank" >1QS100480501: Radionuklidové prekurzory pro syntézu nových radiofarmaceutických přípravků pro terapeutické účely</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Radiation and Isotopes

ISSN

0969-8043

e-ISSN

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Svazek periodika

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Číslo periodika v rámci svazku

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Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000261858700005

EID výsledku v databázi Scopus

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