RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F14%3A00435969" target="_blank" >RIV/61389005:_____/14:00435969 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1140/epjd/e2014-50068-8" target="_blank" >http://dx.doi.org/10.1140/epjd/e2014-50068-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1140/epjd/e2014-50068-8" target="_blank" >10.1140/epjd/e2014-50068-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer

Popis výsledku v původním jazyce

Theoretical modeling is a powerful tool to predict radiation damage of biomolecules such as DNA, proteins and more complex biological targets. In this paper, we present damage distributions along a DNA oligomer irradiated by 10 keV electrons, 1, 2, 5, 10and 20 MeV protons and alpha particles predicted by the simulation tool RADAMOL. The scavengeable damage of base and deoxyribose moieties due to radical attack is more important in the studied system than unscavengeable ionizations of the DNA target andsurrounding bound water layer. Radiation quality does not modify distribution of primary damages along the DNA, but changes overall damage yields. For the first time, electron and hole migration along the DNA macromolecule has been taken into account inthe simulation procedure. The effect of these processes on distribution of DNA damages is demonstrated.

Název v anglickém jazyce

RADAMOL tool: Role of radiation quality and charge transfer in damage distribution along DNA oligomer

Popis výsledku anglicky

Theoretical modeling is a powerful tool to predict radiation damage of biomolecules such as DNA, proteins and more complex biological targets. In this paper, we present damage distributions along a DNA oligomer irradiated by 10 keV electrons, 1, 2, 5, 10and 20 MeV protons and alpha particles predicted by the simulation tool RADAMOL. The scavengeable damage of base and deoxyribose moieties due to radical attack is more important in the studied system than unscavengeable ionizations of the DNA target andsurrounding bound water layer. Radiation quality does not modify distribution of primary damages along the DNA, but changes overall damage yields. For the first time, electron and hole migration along the DNA macromolecule has been taken into account inthe simulation procedure. The effect of these processes on distribution of DNA damages is demonstrated.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

<a href="/cs/project/LD12008" target="_blank" >LD12008: Vliv záření s vysokým LPE na specifickou vazbu proteinů na DNA.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Physical Journal D

ISSN

1434-6060

e-ISSN

—

Svazek periodika

68

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

240-247

Kód UT WoS článku

000346058600009

EID výsledku v databázi Scopus

—