Biophysical simulation tool PARTRAC: Modelling proton beams at therapy-relevant energies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F19%3A00523897" target="_blank" >RIV/61389005:_____/19:00523897 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1093/rpd/ncz197" target="_blank" >https://doi.org/10.1093/rpd/ncz197</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncz197" target="_blank" >10.1093/rpd/ncz197</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biophysical simulation tool PARTRAC: Modelling proton beams at therapy-relevant energies

Popis výsledku v původním jazyce

The biophysical simulation tool PARTRAC has been primarily developed to model radiation physics, chemistry and biology on nanometre to micrometre scales. However, the tool can be applied in simulating radiation effects in an event-by-event manner over macroscopic volumes as well. Benchmark simulations are reported showing that PARTRAC does reproduce the macroscopic Bragg peaks of proton beams, although the penetration depths are underestimated by a few per cent for high-energy beams. PARTRAC also quantifies the increase in DNA damage and its complexity along the beam penetration depth. Enhanced biological effectiveness is predicted in particular within distal Bragg peak parts of therapeutic proton beams.

Název v anglickém jazyce

Biophysical simulation tool PARTRAC: Modelling proton beams at therapy-relevant energies

Popis výsledku anglicky

The biophysical simulation tool PARTRAC has been primarily developed to model radiation physics, chemistry and biology on nanometre to micrometre scales. However, the tool can be applied in simulating radiation effects in an event-by-event manner over macroscopic volumes as well. Benchmark simulations are reported showing that PARTRAC does reproduce the macroscopic Bragg peaks of proton beams, although the penetration depths are underestimated by a few per cent for high-energy beams. PARTRAC also quantifies the increase in DNA damage and its complexity along the beam penetration depth. Enhanced biological effectiveness is predicted in particular within distal Bragg peak parts of therapeutic proton beams.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

—

Svazek periodika

186

Číslo periodika v rámci svazku

2-3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

172-175

Kód UT WoS článku

000530582200006

EID výsledku v databázi Scopus

2-s2.0-85082881470