Relative biological effectiveness in a proton spread-out Bragg peak formed by pencil beam scanning mode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F17%3A00477333" target="_blank" >RIV/61389005:_____/17:00477333 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/17:00319443

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s13246-017-0540-8" target="_blank" >http://dx.doi.org/10.1007/s13246-017-0540-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13246-017-0540-8" target="_blank" >10.1007/s13246-017-0540-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Relative biological effectiveness in a proton spread-out Bragg peak formed by pencil beam scanning mode

Popis výsledku v původním jazyce

In recent years, there is an increased interest in using scanning modes in proton therapy, due to the more conformal dose distributions, thanks to the spot-weighted dose delivery. The dose rate in each spot is however much higher than the dose rate when using passive irradiation modes, which could affect the cell response. The purpose of this work was to investigate how the relative biological effectiveness changes along the spread-out Bragg peak created by protons delivered by the pencil beam scanning mode. Cell survival and micronuclei formation were investigated in four positions along the spread-out Bragg peak for various doses. Monte Carlo simulations were used to estimate the dose-averaged linear energy transfer values in the irradiation positions. The cell survival was found to decrease the deeper the sample was placed in the spread-out Bragg peak, which corresponds to the higher linear energy transfer values found using Monte Carlo simulations. The micronuclei frequencies indicate more complex cell injuries at that distal position compared to the proximal part of the spread-out Bragg peak. The relative biological effectiveness determined in this study varies significantly and systematically from 1.1, which is recommended value by the International Commission on Radiation Units, in all the studied positions. In the distal position of spread-out Bragg peak the relative biological effectiveness values were found to be 2.05 +/- 0.44, 1.85 +/- 0.42, 1.53 +/- 0.38 for survival levels 90, 50 and 10%, respectively.

Název v anglickém jazyce

Relative biological effectiveness in a proton spread-out Bragg peak formed by pencil beam scanning mode

Popis výsledku anglicky

In recent years, there is an increased interest in using scanning modes in proton therapy, due to the more conformal dose distributions, thanks to the spot-weighted dose delivery. The dose rate in each spot is however much higher than the dose rate when using passive irradiation modes, which could affect the cell response. The purpose of this work was to investigate how the relative biological effectiveness changes along the spread-out Bragg peak created by protons delivered by the pencil beam scanning mode. Cell survival and micronuclei formation were investigated in four positions along the spread-out Bragg peak for various doses. Monte Carlo simulations were used to estimate the dose-averaged linear energy transfer values in the irradiation positions. The cell survival was found to decrease the deeper the sample was placed in the spread-out Bragg peak, which corresponds to the higher linear energy transfer values found using Monte Carlo simulations. The micronuclei frequencies indicate more complex cell injuries at that distal position compared to the proximal part of the spread-out Bragg peak. The relative biological effectiveness determined in this study varies significantly and systematically from 1.1, which is recommended value by the International Commission on Radiation Units, in all the studied positions. In the distal position of spread-out Bragg peak the relative biological effectiveness values were found to be 2.05 +/- 0.44, 1.85 +/- 0.42, 1.53 +/- 0.38 for survival levels 90, 50 and 10%, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10304 - Nuclear physics

Projekt

<a href="/cs/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Příprava, modifikace a charakterizace materiálů zářením</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE

ISSN

0158-9938

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

359-368

Kód UT WoS článku

000404137700011

EID výsledku v databázi Scopus

2-s2.0-85015638385