First independent validation of the proton-boron capture therapy concept

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F24%3A00598030" target="_blank" >RIV/61389005:_____/24:00598030 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/24:00380584 RIV/00064190:_____/24:10001315

Výsledek na webu

<a href="https://doi.org/10.1038/s41598-024-69370-y" target="_blank" >https://doi.org/10.1038/s41598-024-69370-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-024-69370-y" target="_blank" >10.1038/s41598-024-69370-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

First independent validation of the proton-boron capture therapy concept

Popis výsledku v původním jazyce

Boron has been suggested to enhance the biological effectiveness of proton beams in the Bragg peak region via the p + 11B -> 3 alpha nuclear capture reaction. However, a number of groups have observed no such enhancement in vitro or questioned its proposed mechanism recently. To help elucidate this phenomenon, we irradiated DU145 prostate cancer or U-87 MG glioblastoma cells by clinical 190 MeV proton beams in plateau or Bragg peak regions with or without 10B or 11B isotopes added as sodium mercaptododecaborate (BSH). The results demonstrate that 11B but not 10B or other components of the BSH molecule enhance cell killing by proton beams. The enhancement occurs selectively in the Bragg peak region, is present for boron concentrations as low as 40 ppm, and is not due to secondary neutrons. The enhancement is likely initiated by proton-boron capture reactions producing three alpha particles, which are rare events occurring in a few cells only, and their effects are amplified by intercellular communication to a population-level response. The observed up to 2-3-fold reductions in survival levels upon the presence of boron for the studied prostate cancer or glioblastoma cells suggest promising clinical applications for these tumour types.

Název v anglickém jazyce

First independent validation of the proton-boron capture therapy concept

Popis výsledku anglicky

Boron has been suggested to enhance the biological effectiveness of proton beams in the Bragg peak region via the p + 11B -> 3 alpha nuclear capture reaction. However, a number of groups have observed no such enhancement in vitro or questioned its proposed mechanism recently. To help elucidate this phenomenon, we irradiated DU145 prostate cancer or U-87 MG glioblastoma cells by clinical 190 MeV proton beams in plateau or Bragg peak regions with or without 10B or 11B isotopes added as sodium mercaptododecaborate (BSH). The results demonstrate that 11B but not 10B or other components of the BSH molecule enhance cell killing by proton beams. The enhancement occurs selectively in the Bragg peak region, is present for boron concentrations as low as 40 ppm, and is not due to secondary neutrons. The enhancement is likely initiated by proton-boron capture reactions producing three alpha particles, which are rare events occurring in a few cells only, and their effects are amplified by intercellular communication to a population-level response. The observed up to 2-3-fold reductions in survival levels upon the presence of boron for the studied prostate cancer or glioblastoma cells suggest promising clinical applications for these tumour types.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/GA21-06451S" target="_blank" >GA21-06451S: Záhada zvýšení buněčné odezvy indukované protony v přítomnosti boru</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

19264

Kód UT WoS článku

001295308500085

EID výsledku v databázi Scopus

2-s2.0-85201637908