Study of gold nanoparticle transport by M13 phages towards disease tissues as targeting procedure for radiotherapy applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F19%3A00518413" target="_blank" >RIV/61389005:_____/19:00518413 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/s13404-019-00266-w" target="_blank" >https://doi.org/10.1007/s13404-019-00266-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13404-019-00266-w" target="_blank" >10.1007/s13404-019-00266-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study of gold nanoparticle transport by M13 phages towards disease tissues as targeting procedure for radiotherapy applications

Popis výsledku v původním jazyce

This work introduces an innovative new method to transport gold nanoparticles (Au-NPs) toward specific organs using as transporter the M13 filamentous phage. The aim is to improve the radiotherapy efficiency by injecting gold nanoparticles in the tumor tissues in order to increase the effective atomic number and, consequently, to produce higher locally deposited doses. The biocompatible Au-NPs can be bonded to the phage surface for their transport in the biological fluids and tissues. M13 phages can be prepared to arrive in specific tissues and organs depending on their biochemical preparation and functionalization. Evidence about the real attachment of spherical Au-NPs, 10 nm in diameter, to the M13 phages is obtained using different microscopies. Other analyses have been also performed to evaluate the number of gold nanoparticles that can be transported by M13 phages inside the organism. Our results on the study of the spherical Au-NP size distribution, deduced by AFM, EFM, and TEM analyses, have indicated that in average, 2 couples of Au-NPs are attached to each phage. Moreover, the size of the NPs ranges between 10 and 30 nm, demonstrating a little aggregation of the nanoparticles, which remain usefully sized to be vehicled with the blood flux towards specific organs.

Název v anglickém jazyce

Study of gold nanoparticle transport by M13 phages towards disease tissues as targeting procedure for radiotherapy applications

Popis výsledku anglicky

This work introduces an innovative new method to transport gold nanoparticles (Au-NPs) toward specific organs using as transporter the M13 filamentous phage. The aim is to improve the radiotherapy efficiency by injecting gold nanoparticles in the tumor tissues in order to increase the effective atomic number and, consequently, to produce higher locally deposited doses. The biocompatible Au-NPs can be bonded to the phage surface for their transport in the biological fluids and tissues. M13 phages can be prepared to arrive in specific tissues and organs depending on their biochemical preparation and functionalization. Evidence about the real attachment of spherical Au-NPs, 10 nm in diameter, to the M13 phages is obtained using different microscopies. Other analyses have been also performed to evaluate the number of gold nanoparticles that can be transported by M13 phages inside the organism. Our results on the study of the spherical Au-NP size distribution, deduced by AFM, EFM, and TEM analyses, have indicated that in average, 2 couples of Au-NPs are attached to each phage. Moreover, the size of the NPs ranges between 10 and 30 nm, demonstrating a little aggregation of the nanoparticles, which remain usefully sized to be vehicled with the blood flux towards specific organs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Příprava, modifikace a charakterizace materiálů zářením</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gold Bulletin

ISSN

2364-821X

e-ISSN

2190-7579

Svazek periodika

52

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

135-144

Kód UT WoS článku

000500786900003

EID výsledku v databázi Scopus

2-s2.0-85075245198