PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00392996" target="_blank" >RIV/61389013:_____/13:00392996 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.reactfunctpolym.2013.05.011" target="_blank" >http://dx.doi.org/10.1016/j.reactfunctpolym.2013.05.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.reactfunctpolym.2013.05.011" target="_blank" >10.1016/j.reactfunctpolym.2013.05.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins

Popis výsledku v původním jazyce

Monodisperse poly(styrene-co-divinylbenzene) [P(St-DVB)] microspheres were prepared by the precipitation polymerization of styrene (St) and divinylbenzene (DVB) in acetonitrile (ACN). Effect of St/DVB ratio and monomer concentration on morphology and particle size was investigated. Monodisperse 4.1 m P(St-DVB) microspheres were chloromethylated with chloromethyl methyl ether (CMME) and hypercrosslinked using anhydrous FeCl3 as a catalyst to form a very fine porous structure and to introduce reactive chloromethyl groups in the resulting product denoted as HC-P(St-DVB) particles. The hypercrosslinked microspheres were then functionalized with amino groups to yield HC-P(St-DVB)-NH2 particles and iron oxide was precipitated within their pores. The obtainedmicroparticles were highly magnetic with iron content 38 wt% Fe. The surface of the magnetic microspheres was newly hydrophilized with methoxy-poly(ethylene glycol) (methoxy-PEG) which was confirmed by ATR FT-IR spectroscopy. The poly(et

Název v anglickém jazyce

PEG-modified magnetic hypercrosslinked poly(styrene-co-divinylbenzene) microspheres to minimize sorption of serum proteins

Popis výsledku anglicky

Monodisperse poly(styrene-co-divinylbenzene) [P(St-DVB)] microspheres were prepared by the precipitation polymerization of styrene (St) and divinylbenzene (DVB) in acetonitrile (ACN). Effect of St/DVB ratio and monomer concentration on morphology and particle size was investigated. Monodisperse 4.1 m P(St-DVB) microspheres were chloromethylated with chloromethyl methyl ether (CMME) and hypercrosslinked using anhydrous FeCl3 as a catalyst to form a very fine porous structure and to introduce reactive chloromethyl groups in the resulting product denoted as HC-P(St-DVB) particles. The hypercrosslinked microspheres were then functionalized with amino groups to yield HC-P(St-DVB)-NH2 particles and iron oxide was precipitated within their pores. The obtainedmicroparticles were highly magnetic with iron content 38 wt% Fe. The surface of the magnetic microspheres was newly hydrophilized with methoxy-poly(ethylene glycol) (methoxy-PEG) which was confirmed by ATR FT-IR spectroscopy. The poly(et

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Reactive and Functional Polymers

ISSN

1381-5148

e-ISSN

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Svazek periodika

73

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

1122-1129

Kód UT WoS článku

000322101400017

EID výsledku v databázi Scopus

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