Temperature-induced formation of polymeric nanoparticles: in situ SAXS and QENS experiments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00421775" target="_blank" >RIV/61389013:_____/13:00421775 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/macp.201300415" target="_blank" >http://dx.doi.org/10.1002/macp.201300415</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/macp.201300415" target="_blank" >10.1002/macp.201300415</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Temperature-induced formation of polymeric nanoparticles: in situ SAXS and QENS experiments

Popis výsledku v původním jazyce

Early stages of polymeric nanoparticle formation are monitored by in situ synchrotron small-angle X-ray scattering (SAXS) experiments. A new strategy enables the preparation of stable polymeric nanoparticles from homopolymers (not copolymers) of one typeonly and without any assembly-triggering additives. Poly(ethylacrylic acid) (PEA) in an aqueous solution is tuned to the pH, where it exhibits thermosensitivity and the formation of nanoparticles is temperature-induced. The kinetics of this formation are clearly monitored by SAXS. Experiments indicate the slightly elongated, not exactly spherical shape of the resulting nanoparticles, which is also confirmed by cryo-transmission electron microscopy (cryo-TEM). Quasielastic neutron scattering (QENS) shows that the PEA nanoparticles are relatively loose with a lot of solvent inside, in agreement with results from previous light scattering work.

Název v anglickém jazyce

Temperature-induced formation of polymeric nanoparticles: in situ SAXS and QENS experiments

Popis výsledku anglicky

Early stages of polymeric nanoparticle formation are monitored by in situ synchrotron small-angle X-ray scattering (SAXS) experiments. A new strategy enables the preparation of stable polymeric nanoparticles from homopolymers (not copolymers) of one typeonly and without any assembly-triggering additives. Poly(ethylacrylic acid) (PEA) in an aqueous solution is tuned to the pH, where it exhibits thermosensitivity and the formation of nanoparticles is temperature-induced. The kinetics of this formation are clearly monitored by SAXS. Experiments indicate the slightly elongated, not exactly spherical shape of the resulting nanoparticles, which is also confirmed by cryo-transmission electron microscopy (cryo-TEM). Quasielastic neutron scattering (QENS) shows that the PEA nanoparticles are relatively loose with a lot of solvent inside, in agreement with results from previous light scattering work.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP108%2F12%2F0640" target="_blank" >GAP108/12/0640: Biokompatibilní nanodimantové sondy pro multimodální zobrazování in vivo</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular Chemistry and Physics

ISSN

1022-1352

e-ISSN

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Svazek periodika

214

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

2841-2847

Kód UT WoS článku

000329021400008

EID výsledku v databázi Scopus

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