Understanding the structural parameters of biocompatible nanoparticles dictating protein fouling
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00431000" target="_blank" >RIV/61389013:_____/14:00431000 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1021/la502179f" target="_blank" >http://dx.doi.org/10.1021/la502179f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/la502179f" target="_blank" >10.1021/la502179f</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Understanding the structural parameters of biocompatible nanoparticles dictating protein fouling
Popis výsledku v původním jazyce
The development of nanocarriers for biomedical applications requires that these nanocarriers have special properties, including resistance to nonspecific protein adsorption. In this study, the fouling properties of PLA- and PCL-based block copolymer nanoparticles (NPs) have been evaluated by placing them in contact with model proteins. Block copolymer NPs were produced through the self-assembly of PEOm-b-PLAn and PEOm-b-PCLn. This procedure yielded nanosized objects with distinct structural features dependent on the length of the hydrophobic and hydrophilic blocks and the volume ratio. The protein adsorption events were examined in relation to size, chain length, surface curvature, and hydrophilic chain density. Fouling by BSA and lysozyme was considerably reduced as the length of the hydrophilic PEO-stabilizing shell increases. In contrast to the case of hydrophilic polymer-grafted planar surfaces, the current investigations suggest that the hydrophilic chain density did not markedly
Název v anglickém jazyce
Understanding the structural parameters of biocompatible nanoparticles dictating protein fouling
Popis výsledku anglicky
The development of nanocarriers for biomedical applications requires that these nanocarriers have special properties, including resistance to nonspecific protein adsorption. In this study, the fouling properties of PLA- and PCL-based block copolymer nanoparticles (NPs) have been evaluated by placing them in contact with model proteins. Block copolymer NPs were produced through the self-assembly of PEOm-b-PLAn and PEOm-b-PCLn. This procedure yielded nanosized objects with distinct structural features dependent on the length of the hydrophobic and hydrophilic blocks and the volume ratio. The protein adsorption events were examined in relation to size, chain length, surface curvature, and hydrophilic chain density. Fouling by BSA and lysozyme was considerably reduced as the length of the hydrophilic PEO-stabilizing shell increases. In contrast to the case of hydrophilic polymer-grafted planar surfaces, the current investigations suggest that the hydrophilic chain density did not markedly
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CF - Fyzikální chemie a teoretická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymerní částice a nanostrukturované materiály stabilizované povrchově aktivními molekulami</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Langmuir
ISSN
0743-7463
e-ISSN
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Svazek periodika
30
Číslo periodika v rámci svazku
32
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
9770-9779
Kód UT WoS článku
000340701300017
EID výsledku v databázi Scopus
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