Macroporous 2-hydroxyethyl methacrylate hydrogels of dual porosity for cell cultivation: morphology, swelling, permeability, and mechanical behavior

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00435661" target="_blank" >RIV/61389013:_____/14:00435661 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10965-014-0579-0" target="_blank" >http://dx.doi.org/10.1007/s10965-014-0579-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10965-014-0579-0" target="_blank" >10.1007/s10965-014-0579-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Macroporous 2-hydroxyethyl methacrylate hydrogels of dual porosity for cell cultivation: morphology, swelling, permeability, and mechanical behavior

Popis výsledku v původním jazyce

Macroporous hydrogels of dual porosity based on cross-linked poly(2-hydroxyethyl methacrylate) (pHEMA) were prepared, and their swelling, mechanical responses, and hydraulic permeability, as well as cell adhesion and proliferation, were examined on gel-based scaffolds. Large pores on the order of tens and hundreds of microns were generated by adding a solid porogen (fractionated particles of sodium chloride) to the polymerization mixture, which was subsequently washed out of the gel. Small pores on theorder of a few microns were formed by the reaction-induced phase separation mechanism caused by addition of a diluent (1-dodecanol), which is a poor solvent for pHEMA. Morphological studies using light and electron microscopy techniques revealed that thelarge pores were embedded in the pHEMA matrix containing small fused spherical pores. Mechanical behavior of the dual-porosity hydrogels characterized by oscillatory shear measurements revealed that despite very high pore volume, the hyd

Název v anglickém jazyce

Macroporous 2-hydroxyethyl methacrylate hydrogels of dual porosity for cell cultivation: morphology, swelling, permeability, and mechanical behavior

Popis výsledku anglicky

Macroporous hydrogels of dual porosity based on cross-linked poly(2-hydroxyethyl methacrylate) (pHEMA) were prepared, and their swelling, mechanical responses, and hydraulic permeability, as well as cell adhesion and proliferation, were examined on gel-based scaffolds. Large pores on the order of tens and hundreds of microns were generated by adding a solid porogen (fractionated particles of sodium chloride) to the polymerization mixture, which was subsequently washed out of the gel. Small pores on theorder of a few microns were formed by the reaction-induced phase separation mechanism caused by addition of a diluent (1-dodecanol), which is a poor solvent for pHEMA. Morphological studies using light and electron microscopy techniques revealed that thelarge pores were embedded in the pHEMA matrix containing small fused spherical pores. Mechanical behavior of the dual-porosity hydrogels characterized by oscillatory shear measurements revealed that despite very high pore volume, the hyd

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP108%2F12%2F1538" target="_blank" >GAP108/12/1538: MIKROSTRUKTUROVANÉ HYDROGELY PRO TKÁŇOVÉ INŽENÝRSTVÍ: VISKOELASTICKÉ ODEZVY GELU O RUZNÉ MORFOLOGICKÉ STRUKTUŘE.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Polymer Research

ISSN

1022-9760

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

TW - Čínská republika (Tchaj-wan)

Počet stran výsledku

12

Strana od-do

"579_1"-"579_12"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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