Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00478611" target="_blank" >RIV/61389013:_____/17:00478611 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/17:00478611 RIV/61388971:_____/17:00478611 RIV/68378050:_____/17:00478611 RIV/00216208:11110/17:10364673 RIV/00023001:_____/17:00076182

Výsledek na webu

<a href="http://dx.doi.org/10.1039/C7RA08712H" target="_blank" >http://dx.doi.org/10.1039/C7RA08712H</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C7RA08712H" target="_blank" >10.1039/C7RA08712H</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models

Popis výsledku v původním jazyce

Nanoparticles are constructs that can be used for cellular interventions and targeted drug delivery. They are useful for overcoming the dose-related toxic effects of drugs or diagnostic preparations by predominant or selective accumulation in the pathologic tissues. Gadolinium(III) compounds are largely used as contrast agents in magnetic resonance imaging but may have toxic effects, especially in nephropathic patients, due to the dose required for use in MRI. Here, we describe the preparation of new multifunctional NaGdF4:Yb3+/Er3+ nanoparticles, their characteristic properties, and some preliminary data about their effect on cell viability and tissue localization. Hexagonal-phase NaGdF4 nanocrystals that were doped with optically active Yb3+ and Er3+ ions, were synthesized by coprecipitation of lanthanide chlorides in octadec-1-ene at high temperature, stabilized by oleic acid, and subsequently coated with a thin silica layer. The morphology, elemental composition, crystalline structure, and SiO2 coating of the prepared NaGdF4:Yb3+/Er3+@SiO2 nanoparticles were characterized in detail by transmission electron microscopy combined with energy-dispersive spectroscopy and selected area electron diffraction and attenuated total reflection Fourier transform infrared (ATR FTIR) spectroscopy. The upconversion and paramagnetic properties of the particles were measured using confocal microscopy and MRI, respectively. The biocompatibility of the NaGdF4:Yb3+/Er3+@SiO2 nanoparticles was tested in vitro using mouse 3T3 fibroblasts and B16F10 melanoma cells. Particle localization was evaluated ex vivo in tumor, liver, and brain tissues of B16F10 melanoma bearing mice after intravenous administration. The NaGdF4:Yb3+/Er3+@SiO2 particles proved to be non-toxic at moderate concentrations. Particle localization within the organs was demonstrated by analysis of the tissues using laser ablation inductively coupled plasma mass spectrometry and showed vascular localization.

Název v anglickém jazyce

Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models

Popis výsledku anglicky

Nanoparticles are constructs that can be used for cellular interventions and targeted drug delivery. They are useful for overcoming the dose-related toxic effects of drugs or diagnostic preparations by predominant or selective accumulation in the pathologic tissues. Gadolinium(III) compounds are largely used as contrast agents in magnetic resonance imaging but may have toxic effects, especially in nephropathic patients, due to the dose required for use in MRI. Here, we describe the preparation of new multifunctional NaGdF4:Yb3+/Er3+ nanoparticles, their characteristic properties, and some preliminary data about their effect on cell viability and tissue localization. Hexagonal-phase NaGdF4 nanocrystals that were doped with optically active Yb3+ and Er3+ ions, were synthesized by coprecipitation of lanthanide chlorides in octadec-1-ene at high temperature, stabilized by oleic acid, and subsequently coated with a thin silica layer. The morphology, elemental composition, crystalline structure, and SiO2 coating of the prepared NaGdF4:Yb3+/Er3+@SiO2 nanoparticles were characterized in detail by transmission electron microscopy combined with energy-dispersive spectroscopy and selected area electron diffraction and attenuated total reflection Fourier transform infrared (ATR FTIR) spectroscopy. The upconversion and paramagnetic properties of the particles were measured using confocal microscopy and MRI, respectively. The biocompatibility of the NaGdF4:Yb3+/Er3+@SiO2 nanoparticles was tested in vitro using mouse 3T3 fibroblasts and B16F10 melanoma cells. Particle localization was evaluated ex vivo in tumor, liver, and brain tissues of B16F10 melanoma bearing mice after intravenous administration. The NaGdF4:Yb3+/Er3+@SiO2 particles proved to be non-toxic at moderate concentrations. Particle localization within the organs was demonstrated by analysis of the tissues using laser ablation inductively coupled plasma mass spectrometry and showed vascular localization.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

73

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

45997-46006

Kód UT WoS článku

000412211300014

EID výsledku v databázi Scopus

2-s2.0-85030655552