Fluorinated 2-alkyl-2-oxazolines of high reactivity: spacer-length-induced acceleration for cationic ring-opening polymerization as a basis for triphilic block copolymer synthesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00483138" target="_blank" >RIV/61389013:_____/18:00483138 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acsmacrolett.7b00954" target="_blank" >http://dx.doi.org/10.1021/acsmacrolett.7b00954</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsmacrolett.7b00954" target="_blank" >10.1021/acsmacrolett.7b00954</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fluorinated 2-alkyl-2-oxazolines of high reactivity: spacer-length-induced acceleration for cationic ring-opening polymerization as a basis for triphilic block copolymer synthesis

Popis výsledku v původním jazyce

The synthesis of defined triphilic terpolymers with hydrophilic, lyophilic, and fluorophilic blocks is an important challenge as a basis for the development of multicompartment self-assembled structures with potential for, e.g., cascade catalysis and multidrug loading. The synthesis of fluorophilic poly(2-oxazoline)s generally suffers from a very low reactivity of fluorinated 2-oxazoline monomers in cationic ring-opening polymerization (CROP). We report a systematic study on overcoming the extremely low reactivity of 2-perfluoroalkyl-2-oxazolines in CROP by the insertion of methyl and ethyl hydrocarbon spacers between the 2-oxazoline ring and the trifluoromethyl group. The kinetic studies showed the gradual increase of the rate of polymerization with increasing of the hydrocarbon spacer length. The monomer with an ethyl spacer was found to have similar reactivity as 2-alkyl-2-oxazolines and allowed the synthesis of defined triphilic triblock copolymers.

Název v anglickém jazyce

Fluorinated 2-alkyl-2-oxazolines of high reactivity: spacer-length-induced acceleration for cationic ring-opening polymerization as a basis for triphilic block copolymer synthesis

Popis výsledku anglicky

The synthesis of defined triphilic terpolymers with hydrophilic, lyophilic, and fluorophilic blocks is an important challenge as a basis for the development of multicompartment self-assembled structures with potential for, e.g., cascade catalysis and multidrug loading. The synthesis of fluorophilic poly(2-oxazoline)s generally suffers from a very low reactivity of fluorinated 2-oxazoline monomers in cationic ring-opening polymerization (CROP). We report a systematic study on overcoming the extremely low reactivity of 2-perfluoroalkyl-2-oxazolines in CROP by the insertion of methyl and ethyl hydrocarbon spacers between the 2-oxazoline ring and the trifluoromethyl group. The kinetic studies showed the gradual increase of the rate of polymerization with increasing of the hydrocarbon spacer length. The monomer with an ethyl spacer was found to have similar reactivity as 2-alkyl-2-oxazolines and allowed the synthesis of defined triphilic triblock copolymers.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA17-00973S" target="_blank" >GA17-00973S: Lipidová kubická fáze pro podávání léků a nanokrystalizaci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Macro Letters

ISSN

2161-1653

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

7-10

Kód UT WoS článku

000423016200002

EID výsledku v databázi Scopus

2-s2.0-85040575229