Inorganic nanomaterials as promoters/inhibitors of amyloid fibril formation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F21%3A00550974" target="_blank" >RIV/61389013:_____/21:00550974 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.wiley.com/en-ie/Biological+Soft+Matter:+Fundamentals,+Properties,+and+Applications-p-9783527343485" target="_blank" >https://www.wiley.com/en-ie/Biological+Soft+Matter:+Fundamentals,+Properties,+and+Applications-p-9783527343485</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Inorganic nanomaterials as promoters/inhibitors of amyloid fibril formation

Popis výsledku v původním jazyce

The exposure of the human population to nanoparticles has been increasing. Inorganic nanoparticles easily penetrate the human body, are biologically active, have a large specific surface area and are able to persist in the environment and accumulate there. Many of them are also promoters/inhibitors of amyloid fibril formation. Amyloidoses are very serious diseases that are characterized by amyloid deposition in various organs and tissues causing their dysfunction. This review addresses the influence of inorganic nanoparticles on the process of amyloid fibril formation, which is a popular topic in nanoparticle science because of associated public health concerns. The effect of nanoparticles on amyloid fibril formation is dependent on several parameters such as nanoparticle size, shape and surface chemistry. It was found that the same type of nanoparticle may have different effects on the process of amyloid fibril formation depending on the model system used. They can promote the fibrillation of some model protein systems, but on the other hand, they can inhibit the fibrillation of others. Some nanoparticles can even decompose amyloid fibrils.

Název v anglickém jazyce

Inorganic nanomaterials as promoters/inhibitors of amyloid fibril formation

Popis výsledku anglicky

The exposure of the human population to nanoparticles has been increasing. Inorganic nanoparticles easily penetrate the human body, are biologically active, have a large specific surface area and are able to persist in the environment and accumulate there. Many of them are also promoters/inhibitors of amyloid fibril formation. Amyloidoses are very serious diseases that are characterized by amyloid deposition in various organs and tissues causing their dysfunction. This review addresses the influence of inorganic nanoparticles on the process of amyloid fibril formation, which is a popular topic in nanoparticle science because of associated public health concerns. The effect of nanoparticles on amyloid fibril formation is dependent on several parameters such as nanoparticle size, shape and surface chemistry. It was found that the same type of nanoparticle may have different effects on the process of amyloid fibril formation depending on the model system used. They can promote the fibrillation of some model protein systems, but on the other hand, they can inhibit the fibrillation of others. Some nanoparticles can even decompose amyloid fibrils.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/LO1507" target="_blank" >LO1507: Polymery pro pokročilé technologie i kvalitnější život</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Biological Soft Matter: Fundamentals, Properties, and Applications

ISBN

978-3-527-34348-5

Počet stran výsledku

34

Strana od-do

195-228

Počet stran knihy

288

Název nakladatele

Wiley-VCH

Místo vydání

Weinheim

Kód UT WoS kapitoly

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