Electron beam irradiation as a straightforward way to produce tailorable non-biofouling poly(2-methyl-2-oxazoline) hydrogel layers on different substrates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00570915" target="_blank" >RIV/61389013:_____/23:00570915 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21220/23:00365895 RIV/00216224:14310/23:00130594

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0169433223007389?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169433223007389?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsusc.2023.157061" target="_blank" >10.1016/j.apsusc.2023.157061</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electron beam irradiation as a straightforward way to produce tailorable non-biofouling poly(2-methyl-2-oxazoline) hydrogel layers on different substrates

Popis výsledku v původním jazyce

Uncontrolled accumulation of proteins and cells on implantable materials often leads to failure of their performance in vivo. The idea presented in this paper is the use of electron beam irradiation as a widely applicable, cost-effective, and defined method to produce non-biofouling hydrogel coatings to improve the biocompatibility and in vivo performance of implantable materials. Statistical copolymers poly[2-methyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline]s were deposited on different substrates and irradiated with beta radiation of different radiation doses (2–100 kGy). In the bulk state experiments, we found that the higher content of crosslinkable 3-butenyl units and a higher radiation dose resulted in more efficient crosslinking. Similarly, the irradiation of coatings demonstrated the high impact of the concentration of 3-butenyl units on crosslinking efficiency. Accordingly, the concentration of crosslinkable double bonds in the copolymer is crucial for the stability and homogeneity of the formed hydrogel layer. Stable and uniform hydrogel layers with thicknesses in the micrometer range were prepared from a 5 wt% copolymer solution. Depending on the preparation conditions, the hydrogel layers showed excellent non-biofouling properties with a low number of adherent cells. In addition, stiffness was dependent on the degree of crosslinking, and can thus be tailored for specific application in living tissue.

Název v anglickém jazyce

Electron beam irradiation as a straightforward way to produce tailorable non-biofouling poly(2-methyl-2-oxazoline) hydrogel layers on different substrates

Popis výsledku anglicky

Uncontrolled accumulation of proteins and cells on implantable materials often leads to failure of their performance in vivo. The idea presented in this paper is the use of electron beam irradiation as a widely applicable, cost-effective, and defined method to produce non-biofouling hydrogel coatings to improve the biocompatibility and in vivo performance of implantable materials. Statistical copolymers poly[2-methyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline]s were deposited on different substrates and irradiated with beta radiation of different radiation doses (2–100 kGy). In the bulk state experiments, we found that the higher content of crosslinkable 3-butenyl units and a higher radiation dose resulted in more efficient crosslinking. Similarly, the irradiation of coatings demonstrated the high impact of the concentration of 3-butenyl units on crosslinking efficiency. Accordingly, the concentration of crosslinkable double bonds in the copolymer is crucial for the stability and homogeneity of the formed hydrogel layer. Stable and uniform hydrogel layers with thicknesses in the micrometer range were prepared from a 5 wt% copolymer solution. Depending on the preparation conditions, the hydrogel layers showed excellent non-biofouling properties with a low number of adherent cells. In addition, stiffness was dependent on the degree of crosslinking, and can thus be tailored for specific application in living tissue.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Surface Science

ISSN

0169-4332

e-ISSN

1873-5584

Svazek periodika

625

Číslo periodika v rámci svazku

15 July

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

157061

Kód UT WoS článku

000976656400001

EID výsledku v databázi Scopus

2-s2.0-85151686747