Meta-isobutoxy phenylboronic acid for nanoscale multi-stimuli-responsive low-molecular-weight hydrogelator

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00575363" target="_blank" >RIV/61389013:_____/23:00575363 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/23:10470954

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acsanm.3c03259" target="_blank" >https://pubs.acs.org/doi/10.1021/acsanm.3c03259</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.3c03259" target="_blank" >10.1021/acsanm.3c03259</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Meta-isobutoxy phenylboronic acid for nanoscale multi-stimuli-responsive low-molecular-weight hydrogelator

Popis výsledku v původním jazyce

Hydrogelators generate hydrogels when dissolved in water, forming a network of interlocking chains on the nanoscale level. For their unique viscoelastic, mechanical, and swelling properties, these hydrogels have found various applications, such as water absorbent, biocompatible, and biodegradable scaffolds in tissue engineering and nanocarriers in drug delivery. When measuring the solubility of p-, m-, and o-isobutoxy derivatives of phenylboronic acid, we identified m-isobutoxyphenylboronic acid (PBA) as a low-molecular-weight hydrogelator, the first of which solely based on phenylboronic acid. At low concentrations, PBA gelated water into a network of cross-linked nanofibers combining amorphous and crystalline phases, as shown by electron and optical microscopy, rheometry, and differential scanning calorimetry and confirmed by small- and wide-angle X-ray scattering. By increasing the PBA concentration, we were able to tailor the elastic modulus (G′) of PBA hydrogels across 2 orders of magnitude, from 2.5 to 103 kPa. In turn, at a specific PBA concentration, we tuned their viscoelastic properties by adding urea, thereby adjusting the gelation temperature between 62 and 56 °C and G′ at body temperature between 63.4 and 30.4 kPa. Moreover, PBA hydrogels dissolved in response to various triggers (pH increase, H2O2 and cyclodextrin addition) and selectively absorbed dyes for liquid mixture separation. These findings demonstrate that PBA has a high potential as a biodegradable, multistimuli-responsive, low-molecular-weight hydrogelator for bioapplications.

Název v anglickém jazyce

Meta-isobutoxy phenylboronic acid for nanoscale multi-stimuli-responsive low-molecular-weight hydrogelator

Popis výsledku anglicky

Hydrogelators generate hydrogels when dissolved in water, forming a network of interlocking chains on the nanoscale level. For their unique viscoelastic, mechanical, and swelling properties, these hydrogels have found various applications, such as water absorbent, biocompatible, and biodegradable scaffolds in tissue engineering and nanocarriers in drug delivery. When measuring the solubility of p-, m-, and o-isobutoxy derivatives of phenylboronic acid, we identified m-isobutoxyphenylboronic acid (PBA) as a low-molecular-weight hydrogelator, the first of which solely based on phenylboronic acid. At low concentrations, PBA gelated water into a network of cross-linked nanofibers combining amorphous and crystalline phases, as shown by electron and optical microscopy, rheometry, and differential scanning calorimetry and confirmed by small- and wide-angle X-ray scattering. By increasing the PBA concentration, we were able to tailor the elastic modulus (G′) of PBA hydrogels across 2 orders of magnitude, from 2.5 to 103 kPa. In turn, at a specific PBA concentration, we tuned their viscoelastic properties by adding urea, thereby adjusting the gelation temperature between 62 and 56 °C and G′ at body temperature between 63.4 and 30.4 kPa. Moreover, PBA hydrogels dissolved in response to various triggers (pH increase, H2O2 and cyclodextrin addition) and selectively absorbed dyes for liquid mixture separation. These findings demonstrate that PBA has a high potential as a biodegradable, multistimuli-responsive, low-molecular-weight hydrogelator for bioapplications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

16055-16064

Kód UT WoS článku

001051309700001

EID výsledku v databázi Scopus

2-s2.0-85169021306