Hyaluronic acid nanoparticles with parameters required for in vivo applications: from synthesis to parametrization

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00588498" target="_blank" >RIV/61389013:_____/24:00588498 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/25:00563507 RIV/00216224:14310/24:00136928 RIV/00216275:25310/24:39921556

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.4c00370" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.4c00370</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.biomac.4c00370" target="_blank" >10.1021/acs.biomac.4c00370</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hyaluronic acid nanoparticles with parameters required for in vivo applications: from synthesis to parametrization

Popis výsledku v původním jazyce

Hyaluronic acid is an excellent biocompatible material for in vivo applications. Its ability to bind CD44, a cell receptor involved in numerous biological processes, predetermines HA-based nanomaterials as unique carrier for therapeutic and theranostic applications. Although numerous methods for the synthesis of hyaluronic acid nanoparticles (HANPs) are available today, their low reproducibility and wide size distribution hinder the precise assessment of the effect on the organism. A robust and reproducible approach for producing HANPs that meet strict criteria for in vivo applications (e.g., to lung parenchyma) remains challenging. We designed and evaluated four protocols for the preparation of HANPs with those required parameters. The HA molecule was cross-linked by novel combinations of carbodiimide, and four different amine-containing compounds resulted in monodisperse HANPs with a low polydispersity index. By a complex postsynthetic characterization, we confirmed that the prepared HANPs meet the criteria for inhaled therapeutic delivery and other in vivo applications.

Název v anglickém jazyce

Hyaluronic acid nanoparticles with parameters required for in vivo applications: from synthesis to parametrization

Popis výsledku anglicky

Hyaluronic acid is an excellent biocompatible material for in vivo applications. Its ability to bind CD44, a cell receptor involved in numerous biological processes, predetermines HA-based nanomaterials as unique carrier for therapeutic and theranostic applications. Although numerous methods for the synthesis of hyaluronic acid nanoparticles (HANPs) are available today, their low reproducibility and wide size distribution hinder the precise assessment of the effect on the organism. A robust and reproducible approach for producing HANPs that meet strict criteria for in vivo applications (e.g., to lung parenchyma) remains challenging. We designed and evaluated four protocols for the preparation of HANPs with those required parameters. The HA molecule was cross-linked by novel combinations of carbodiimide, and four different amine-containing compounds resulted in monodisperse HANPs with a low polydispersity index. By a complex postsynthetic characterization, we confirmed that the prepared HANPs meet the criteria for inhaled therapeutic delivery and other in vivo applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomacromolecules

ISSN

1525-7797

e-ISSN

1526-4602

Svazek periodika

25

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

4934-4945

Kód UT WoS článku

001259876300001

EID výsledku v databázi Scopus

2-s2.0-85197055342