Precise control of molecular weight characteristics of charge-shifting poly(2-(N,N-dimethylamino)ethylacrylate) synthesized by reversible addition-fragmentation chain transfer polymerization

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00605410" target="_blank" >RIV/61389013:_____/25:00605410 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/marc.202400640" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/marc.202400640</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/marc.202400640" target="_blank" >10.1002/marc.202400640</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Precise control of molecular weight characteristics of charge-shifting poly(2-(N,N-dimethylamino)ethylacrylate) synthesized by reversible addition-fragmentation chain transfer polymerization

Popis výsledku v původním jazyce

Poly(2-(N,N-dimethylamino)ethyl acrylate) (PDMAEA) is a promising charge-shifting polycation with the capacity to form a range of morphologically distinct polyelectrolyte assemblies. Nevertheless, the basic character of the monomer and its hydrolytic instability impedes its controlled synthesis to higher molecular weight (MW). Herein, the reversible addition-fragmentation chain transfer polymerization of DMAEA is reported using a tert-butanol/V70 initiator/trithiocarbonate-based chain transfer agent (CTA) polymerization setup. The CTA instability is demonstrated in the presence of the unprotonated tertiary amino group of the DMAEA monomer, which limits the control over the conversion and MW of the polymer. In contrast, the shielding of the amino groups by their protonation leads to polymerization with high conversions and excellent control over MWs of polymer up to 100 000 g mol−1. Hydrolytic degradation study at pH values ranging from 5 to 9 reveals that both basic and protonated PDMAEA undergo a pH-dependent hydrolysis. The proposed polymerization conditions provide a means of synthesizing PDMAEA with well-controlled characteristics, which are beneficial for controlling the complexation processes during the formation of various polyelectrolyte assemblies.

Název v anglickém jazyce

Precise control of molecular weight characteristics of charge-shifting poly(2-(N,N-dimethylamino)ethylacrylate) synthesized by reversible addition-fragmentation chain transfer polymerization

Popis výsledku anglicky

Poly(2-(N,N-dimethylamino)ethyl acrylate) (PDMAEA) is a promising charge-shifting polycation with the capacity to form a range of morphologically distinct polyelectrolyte assemblies. Nevertheless, the basic character of the monomer and its hydrolytic instability impedes its controlled synthesis to higher molecular weight (MW). Herein, the reversible addition-fragmentation chain transfer polymerization of DMAEA is reported using a tert-butanol/V70 initiator/trithiocarbonate-based chain transfer agent (CTA) polymerization setup. The CTA instability is demonstrated in the presence of the unprotonated tertiary amino group of the DMAEA monomer, which limits the control over the conversion and MW of the polymer. In contrast, the shielding of the amino groups by their protonation leads to polymerization with high conversions and excellent control over MWs of polymer up to 100 000 g mol−1. Hydrolytic degradation study at pH values ranging from 5 to 9 reveals that both basic and protonated PDMAEA undergo a pH-dependent hydrolysis. The proposed polymerization conditions provide a means of synthesizing PDMAEA with well-controlled characteristics, which are beneficial for controlling the complexation processes during the formation of various polyelectrolyte assemblies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA24-10980S" target="_blank" >GA24-10980S: Bioresponzivní polykationtové vektory pro doručování genetických vakcín</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular Rapid Communications

ISSN

1022-1336

e-ISSN

1521-3927

Svazek periodika

46

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

2400640

Kód UT WoS článku

001357331000001

EID výsledku v databázi Scopus

2-s2.0-85207932091